The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

Goodpasture's disease or anti-glomerular basement membrane disease (anti-GBM-disease)
is included among immune complex small vessel vasculitides. The definition of anti-GBM …

Canonical neutrophil antimicrobial effector mechanisms, such as degranulation, production
of reactive oxygen species, and release of neutrophil extracellular traps (NETs), can result in …

Background In Goodpasture's disease, circulating autoantibodies bind to the
noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane …

Rapidly progressive glomerulonephritis (RPGN) is a life-threatening clinical syndrome and a
morphological manifestation of severe glomerular injury that is marked by a proliferative …

A 47-year-old white man who worked as a professional musician presented to his general
practitioner with a 3-week history of malaise, loss of appetite, slight weight loss, and dark …

Results: The alpha 3 protein constituent of type IV collagen is thought to be the antigen
implicated in Goodpasture's syndrome, wherein the immune system attacks the basement …

Most patients with anti-glomerular basement membrane (anti-GBM) disease present with
rapidly progressive glomerulonephritis with or without pulmonary haemorrhage; however …

Objectives Anti-glomerular basement membrane (GBM) disease is a rare autoantibody-
mediated disorder presenting as rapidly progressive glomerulonephritis, and often with …

Basement membranes are highly specialized extracellular matrices. Once considered inert
scaffolds, basement membranes are now viewed as dynamic and versatile environments …