Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …

Perturbations in cardiac energy metabolism are major contributors to a number of
cardiovascular pathologies. In addition, comorbidities associated with cardiovascular …

Background: Although in vitro studies and investigations in animal models and small clinical
populations have suggested that ceramides may represent an intermediate link between …

Introduction Metabolomics is increasingly being used in the clinical setting for disease
diagnosis, prognosis and risk prediction. Machine learning algorithms are particularly …

Background: Although metabolomic profiling offers promise for the prediction of coronary
heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in …

Current clinical practices focus on a small number of biochemical directly related to the
pathophysiology with patients and thus only describe a very limited metabolome of a patient …

Background: Pathogenesis and diagnostic biomarkers for diseases can be discovered by
metabolomic profiling of human fluids. If the various types of coronary artery disease (CAD) …

The persistent increase in the worldwide burden of type 2 diabetes mellitus (T2D) and the
accompanying rise of its complications, including cardiovascular disease, necessitates our …

Background: As new biomarkers of coronary artery diseases (CAD) emerge via
metabolomics, the underlying functional mechanisms remain to be elucidated. Functional …

Metabolomics helps identify metabolites to characterize/refine perturbations of biological
pathways in living organisms. Pre-analytical, analytical, and post-analytical limitations that …