The role of molecular testing in the differential diagnosis of salivary gland carcinomas

A Skálová, G Stenman, RHW Simpson… - The American journal …, 2018 - journals.lww.com
Salivary gland neoplasms are a morphologically heterogenous group of lesions that are
often diagnostically challenging. In recent years, considerable progress in salivary gland …

Salivary gland carcinoma: novel targets to overcome treatment resistance in advanced disease

L Di Villeneuve, IL Souza, FDS Tolentino… - Frontiers in …, 2020 - frontiersin.org
Salivary gland carcinomas (SGC) account for less than 5% of head and neck malignant
neoplasms, further subcategorized in over 20 histological subtypes. For the most part …

[HTML][HTML] Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study

R Kurzrock, DW Bowles, H Kang, F Meric-Bernstam… - Annals of …, 2020 - Elsevier
Background Systemic therapy options for salivary cancers are limited. MyPathway
(NCT02091141), a phase IIa study, evaluates targeted therapies in non-indicated tumor …

Molecular pathology of salivary gland neoplasms: diagnostic, prognostic, and predictive perspective

MH Toper, S Sarioglu - Advances in anatomic pathology, 2021 - journals.lww.com
Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In
recent years, there has been considerable progress in efforts to reveal the molecular …

[HTML][HTML] The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma

Z Chen, W Ni, JL Li, S Lin, X Zhou, Y Sun, JW Li… - JCI insight, 2021 - ncbi.nlm.nih.gov
No effective systemic treatment is available for patients with unresectable, recurrent, or
metastatic mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy …

[HTML][HTML] Comprehensive genomic profiles of metastatic and relapsed salivary gland carcinomas are associated with tumor type and reveal new routes to targeted …

JS Ross, LM Gay, K Wang, JA Vergilio, J Suh… - Annals of …, 2017 - Elsevier
Background Relapsed/metastatic salivary gland carcinomas (SGCs) have a wide diversity of
histologic subtypes associated with variable clinical aggressiveness and response to local …

Molecular biology and therapeutic targets of primitive tracheal tumors: focus on tumors derived by salivary glands and squamous cell carcinoma

A Marchioni, R Tonelli, AV Samarelli… - International Journal of …, 2023 - mdpi.com
Primary tracheal tumors are rare, constituting approximately 0.1–0.4% of malignant
diseases. Squamous cell carcinoma (SCC) and adenoid cystic carcinoma (ACC) account for …

Pulmonary salivary gland tumor, mucoepidermoid carcinoma: A literature review

S Hu, J Gong, X Zhu, H Lu - Journal of Oncology, 2022 - Wiley Online Library
Pulmonary mucoepidermoid carcinoma (PMEC) is the most common malignant salivary
gland tumor in the lungs and accounts for 0.1‐0.2% of all lung malignancies in adults. It has …

The molecular landscape of breast mucoepidermoid carcinoma

K Venetis, E Sajjadi, M Ivanova, S Andaloro… - Cancer …, 2023 - Wiley Online Library
Mucoepidermoid carcinoma (MEC) of the breast is an extremely rare salivary gland‐type
tumor characterized by epidermoid, basaloid, intermediate, and/or mucinous cells arranged …

p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness

C Rodriguez-Ramirez, Z Zhang, KA Warner… - Clinical Cancer …, 2022 - AACR
Purpose: Mucoepidermoid carcinoma (MEC) is a poorly understood salivary gland
malignancy with limited therapeutic options. Cancer stem cells (CSC) are considered drivers …