[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …
Viscoelasticity, like forces, plays a role in mechanotransduction
CT Mierke - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …
fundamental biological processes in living systems, such as morphogenesis and motility …
[HTML][HTML] SNAIL induces EMT and lung metastasis of tumours secreting CXCL2 to promote the invasion of M2-type immunosuppressed macrophages in colorectal …
Z Bao, W Zeng, D Zhang, L Wang, X Deng… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Background: There is increasing evidence that tumour-associated macrophages (TAMs) are
critical in the formation of lung metastases. However, the molecular mechanisms of tumour …
critical in the formation of lung metastases. However, the molecular mechanisms of tumour …
Dendritic cell phenotype and function in a 3D co-culture model of patient-derived metastatic colorectal cancer organoids
B Subtil, KK Iyer, D Poel, L Bakkerus… - Frontiers in …, 2023 - frontiersin.org
Colorectal cancer (CRC) remains one of the most aggressive and lethal cancers, with
metastasis accounting for most deaths. As such, there is an unmet need for improved …
metastasis accounting for most deaths. As such, there is an unmet need for improved …
In vitro veritas: from 2D cultures to organ-on-a-chip models to study immunogenic cell death in the tumor microenvironment
DV Krysko, R Demuynck, I Efimova, F Naessens… - Cells, 2022 - mdpi.com
Immunogenic cell death (ICD) is a functionally unique form of cell death that promotes a T-
cell-dependent anti-tumor immune response specific to antigens originating from dying …
cell-dependent anti-tumor immune response specific to antigens originating from dying …
[HTML][HTML] Next generation organoid engineering to replace animals in cancer drug testing
S Hockney, J Parker, JE Turner, X Todd… - Biochemical …, 2023 - Elsevier
Cancer therapies have several clinical challenges associated with them, namely treatment
toxicity, treatment resistance and relapse. Due to factors ranging from patient profiles to the …
toxicity, treatment resistance and relapse. Due to factors ranging from patient profiles to the …
Hyperthermic intraperitoneal chemotherapy: a critical review
W Ceelen, J Demuytere, I de Hingh - Cancers, 2021 - mdpi.com
Simple Summary Patients with cancer of the digestive system or ovarian cancer are at risk of
developing peritoneal metastases (PM). In some patients with PM, surgery followed by …
developing peritoneal metastases (PM). In some patients with PM, surgery followed by …
Microfluidic technologies for immunotherapy studies on solid tumours
K Paterson, S Zanivan, R Glasspool, SB Coffelt… - Lab on a Chip, 2021 - pubs.rsc.org
Immunotherapy is a powerful and targeted cancer treatment that exploits the body's immune
system to attack and eliminate cancerous cells. This form of therapy presents the possibility …
system to attack and eliminate cancerous cells. This form of therapy presents the possibility …
Photodynamic therapy-mediated immune responses in three-dimensional tumor models
Photodynamic therapy (PDT) is a promising non-invasive phototherapeutic approach for
cancer therapy that can eliminate local tumor cells and produce systemic antitumor immune …
cancer therapy that can eliminate local tumor cells and produce systemic antitumor immune …
Identification of anoikis-related subtypes and immune landscape in kidney renal clear cell carcinoma
W Ding, M Zhang, P Zhang, X Zhang, J Sun, B Lin - Scientific Reports, 2023 - nature.com
Anoikis is a specific form of programmed cell death induced by the loss of cell contact with
the extracellular matrix and other cells, and plays an important role in organism …
the extracellular matrix and other cells, and plays an important role in organism …