Ribosomes are cellular machines essential for protein synthesis. The biogenesis of
ribosomes is a highly complex and energy consuming process that initiates in the nucleolus …

Ribosomes are essential components of the protein synthesis machinery. The process of
ribosome biogenesis is well organized and tightly regulated. Recent studies have shown …

AMP-activated protein kinase (AMPK) has been shown to activate p53 in response to
metabolic stress. However, the underlying mechanisms remain unclear. Here we show that …

The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent
and-independent stress responses. A variety of abnormal metabolic conditions, cytotoxic …

MDM2 is considered a hub protein due to its capacity to interact with a large number of
different partners of which p53 is most well described. MDM2 is an E3 ubiquitin ligase, and …

The central region of MDM2 is critical for p53 activation and tumor suppression. Upon
ribosomal stress, this region is bound by ribosomal proteins, particularly ribosomal protein …

The tumor suppressor p53 plays a central role in anti-tumorigenesis and cancer therapy. It
has been described as “the guardian of the genome”, because it is essential for conserving …

Oncogene MYC is highly expressed in many human cancers and functions as a global
regulator of ribosome biogenesis. Previously, we reported that ribosomal protein (RP) L11 …

The oncoprotein MDM2 is both the transcriptional target and the predominant antagonist of
the tumor suppressor p53. MDM2 inhibits the functions of p53 via a negative feedback loop …

Abstract p53 is an intrinsically disordered protein with a large number of post-translational
modifications and interacting partners. The hierarchical order and subcellular location of …