Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities

D Lozano, GS Gonzales-Portillo, S Acosta… - Neuropsychiatric …, 2015 - Taylor & Francis
Traumatic brain injury (TBI) is a serious public health problem accounting for 1.4 million
emergency room visits by US citizens each year. Although TBI has been traditionally …

[HTML][HTML] A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury

EP Thelin, DW Nelson, BM Bellander - Acta neurochirurgica, 2017 - Springer
Background In order to improve injury assessment of brain injuries, protein markers of
pathophysiological processes and tissue fate have been introduced in the clinic. The most …

[HTML][HTML] The role of NLRP3 inflammasome in the pathogenesis of traumatic brain injury

N Irrera, M Russo, G Pallio, A Bitto, F Mannino… - International journal of …, 2020 - mdpi.com
Traumatic brain injury (TBI) represents an important problem of global health. The damage
related to TBI is first due to the direct injury and then to a secondary phase in which …

[HTML][HTML] Neuroinflammation in traumatic brain injury: a chronic response to an acute injury

SJ Schimmel, S Acosta, D Lozano - Brain circulation, 2017 - journals.lww.com
Abstract Every year, approximately 1.4 million US citizens visit emergency rooms for
traumatic brain injuries. Formerly known as an acute injury, chronic neurodegenerative …

Melatonin attenuates traumatic brain injury‐induced inflammation: a possible role for mitophagy

C Lin, H Chao, Z Li, X Xu, Y Liu, L Hou… - Journal of pineal …, 2016 - Wiley Online Library
Melatonin functions as a crucial mediator of sterile neuroinflammation; however, the
underlying mechanisms remain poorly understood. Dysfunctional mitochondria, a main …

NLRP3 inflammasome in traumatic brain injury: Its implication in the disease pathophysiology and potential as a therapeutic target

R Chakraborty, H Tabassum, S Parvez - Life sciences, 2023 - Elsevier
Traumatic brain injury (TBI), an acquired brain injury imparted by a mechanical trauma to the
head, has significant ramifications in terms of long-term disability and cost of healthcare. TBI …

[HTML][HTML] Management of traumatic brain injury: from present to future

R Crupi, M Cordaro, S Cuzzocrea, D Impellizzeri - Antioxidants, 2020 - mdpi.com
TBI (traumatic brain injury) is a major cause of death among youth in industrialized societies.
Brain damage following traumatic injury is a result of direct and indirect mechanisms; …

Temporal Profiles of P-Tau, T-Tau, and P-Tau: Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to …

R Rubenstein, L McQuillan, KKW Wang… - Journal of …, 2024 - liebertpub.com
Traumatic brain injury (TBI) can initiate progressive injury responses, which are linked to
increased risk of neurodegenerative diseases known as “tauopathies.” Increased post-TBI …

Acute CSF interleukin-6 trajectories after TBI: associations with neuroinflammation, polytrauma, and outcome

RG Kumar, ML Diamond, JA Boles, RP Berger… - Brain, behavior, and …, 2015 - Elsevier
Traumatic brain injury (TBI) results in a significant inflammatory burden that perpetuates the
production of inflammatory mediators and biomarkers. Interleukin-6 (IL-6) is a pro …

Chronic neurodegenerative consequences of traumatic brain injury

NB Chauhan - Restorative neurology and neuroscience, 2014 - content.iospress.com
Traumatic brain injury (TBI) is a serious public health concern and a major cause of death
and disability worldwide. Each year, an estimated 1.7 million Americans sustain TBI of …