A multi-tissue atlas of regulatory variants in cattle

S Liu, Y Gao, O Canela-Xandri, S Wang, Y Yu, W Cai… - Nature …, 2022 - nature.com
Abstract Characterization of genetic regulatory variants acting on livestock gene expression
is essential for interpreting the molecular mechanisms underlying traits of economic value …

[HTML][HTML] Underlying genetic architecture of resistance to mastitis in dairy cattle: A systematic review and gene prioritization analysis of genome-wide association …

SG Narayana, E de Jong, FS Schenkel… - Journal of Dairy …, 2023 - Elsevier
Mastitis, the most frequent disease in dairy cattle. Resistance to mastitis is a complex,
polygenic trait controlled by several genes, each with small effects. Genome-wide …

Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle

L Fang, W Cai, S Liu, O Canela-Xandri, Y Gao… - Genome …, 2020 - genome.cshlp.org
By uniformly analyzing 723 RNA-seq data from 91 tissues and cell types, we built a
comprehensive gene atlas and studied tissue specificity of genes in cattle. We demonstrated …

[HTML][HTML] Genome-wide association study as an efficacious approach to discover candidate genes associated with body linear type traits in dairy cattle

M Long, B Wang, Z Yang, X Lu - Animals, 2024 - mdpi.com
Simple Summary This study synthesizes reports on body conformation traits in dairy cows,
emphasizing their importance in dairy farming. It elucidates the potential role of these traits …

Pangenome-genotyped structural variation improves molecular phenotype mapping in cattle

AS Leonard, XM Mapel, H Pausch - Genome Research, 2024 - genome.cshlp.org
Expression and splicing quantitative trait loci (e/sQTL) are large contributors to phenotypic
variability. Achieving sufficient statistical power for e/sQTL mapping requires large cohorts …

Comparative transcriptome in large-scale human and cattle populations

Y Yao, S Liu, C Xia, Y Gao, Z Pan, O Canela-Xandri… - Genome biology, 2022 - Springer
Background Cross-species comparison of transcriptomes is important for elucidating
evolutionary molecular mechanisms underpinning phenotypic variation between and within …

Genome-wide association study for udder conformation traits in Chinese Holstein cattle

M Nazar, IM Abdalla, Z Chen, N Ullah, Y Liang, S Chu… - Animals, 2022 - mdpi.com
Simple Summary Udder conformation traits are economically important for dairy animals in
the dairy industry. Milk production loss can be reduced via a better udder structure in dairy …

A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle

YL Lee, H Takeda, G Costa Monteiro Moreira… - PLoS …, 2021 - journals.plos.org
Clinical mastitis (CM) is an inflammatory disease occurring in the mammary glands of
lactating cows. CM is under genetic control, and a prominent CM resistance QTL located on …

Genetic architecture and key regulatory genes of fatty acid composition in Gushi chicken breast muscle determined by GWAS and WGCNA

S Fan, P Yuan, S Li, H Li, B Zhai, Y Li, H Zhang, J Gu… - BMC genomics, 2023 - Springer
Background Fatty acids composition in poultry muscle is directly related to its tenderness,
flavour, and juiciness, whereas its genetic mechanisms have not been elucidated. In this …

Comparative epigenomics reveals the impact of ruminant-specific regulatory elements on complex traits

S Chen, S Liu, S Shi, Y Jiang, M Cao, Y Tang, W Li… - BMC biology, 2022 - Springer
Background Insights into the genetic basis of complex traits and disease in both human and
livestock species have been achieved over the past decade through detection of genetic …