Heparan sulfate (HS) polysaccharides are ubiquitous components of the cell surface and
extracellular matrix of all multicellular animals, whereas heparin is present within mast cells …

▪ Abstract Virtually every cell type in metazoan organisms produces heparan sulfate. These
complex polysaccharides provide docking sites for numerous protein ligands and receptors …

Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …

Sulfatases, which cleave sulfate esters in biological systems, play a key role in regulating
the sulfation states that determine the function of many physiological molecules. Sulfatase …

The 6-O sulfation states of cell surface heparan sulfate proteoglycans (HSPGs) are
dynamically regulated to control the growth and specification of embryonic progenitor …

Extracellular modulation of phenotype is an emerging paradigm in this current postgenomics
age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of …

Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …

The sulfated domains of HS are the main regions involved in the recognition of growth
factors and other proteins. They are separated by flexible spacers of low sulfation. Although …

Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and
heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with …

Keratinocyte growth factor (KGF) is a paracrine-acting, epithelial mitogen produced by cells
of mesenchymal origin. It is a member of the fibroblast growth factor (FGF) family, and acts …