Studying cell metabolism serves a plethora of objectives such as the enhancement of
bioprocess performance, and advancement in the understanding of cell biology, of drug …

Highlights•Metabolic models of different types (eg single cell/tissue specific/whole-
organism).•Ever-increasing applications of metabolic models.•Model reconstruction process …

Photorespiration (PR) is the pathway that detoxifies the product of the oxygenation reaction
of Rubisco. It has been hypothesized that in dynamic light environments, PR provides a …

Key aspects of leaf mitochondrial metabolism in the light remain unresolved. For example,
there is debate about the relative importance of exporting reducing equivalents from …

Background Pseudomonas putida is a promising candidate for the industrial production of
biofuels and biochemicals because of its high tolerance to toxic compounds and its ability to …

Peatlands harbour more than one‐third of terrestrial carbon leading to the argument that the
bryophytes, as major components of peatland ecosystems, store more organic carbon in …

Metabolic engineering uses microorganisms to synthesize chemicals from renewable
resources. Given the thousands of known metabolites, it is unclear what valuable chemicals …

Elementary flux modes (EFMs) are non-decomposable steady-state pathways in metabolic
networks. They characterize phenotypes, quantify robustness or identify engineering targets …

Recent progress in synthetic biology allows the construction of dynamic control circuits for
metabolic engineering. This technology promises to overcome many challenges …

Reaction-equilibrium constants determine the metabolite concentrations necessary to drive
flux through metabolic pathways. Group-contribution methods offer a way to estimate …