Several new studies have shown that an association exists between oral diseases and
systemic chronic diseases. Inflammation has additionally been recognized as the key factor …

Background: The incidence of dementia is projected to rise over the coming decades, but
with no sensitive diagnostic tests available. Vascular pathology precedes the deposition of …

Dementia is a common cause of disability and dependency among the elderly due to its
progressive neurodegenerative nature. As there is currently no curative therapy, it is of major …

Dementia resulting from small vessel diseases (SVDs) of the brain is an emerging epidemic
for which there is no treatment. Hypertension is the major risk factor for SVDs, but how …

Although antihypertensive medication is usually continued indefinitely, observations during
wash-out phases in hypertension trials have shown that withdrawal of antihypertensive …

Among people living with dementia (PLWD) there is a high prevalence of comorbid medical
conditions but little is known about the effects of comorbidity on processes and quality of …

Vascular risk factors and cerebral blood flow (CBF) reduction have been linked to increased
risk of cognitive impairment and Alzheimer's disease (AD); however the possible moderating …

Objectives This study was designed to explore the appropriate blood pressure (BP) target
required to reduce cognitive decline and brain white matter lesions (WMLs) in elderly …

Objectives To assess the effect of cardiovascular diseases and risk factors on mortality in
individuals with dementia. Design Systematic review and meta‐analysis. English‐and Dutch …

The pathogenesis of hypertension-related cognitive impairment has not been sufficiently
clarified, new molecular targets are needed. p38 MAPK pathway plays an important role in …