Pathogenicity and virulence of Clostridioides difficile

JE Buddle, RP Fagan - Virulence, 2023 - Taylor & Francis
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated
diarrhea, and is responsible for a spectrum of diseases characterized by high levels of …

Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …

Reference Susceptibility Testing and Genomic Surveillance of Clostridioides difficile, United States, 2012–17

AS Gargis, M Karlsson, AL Paulick… - Clinical Infectious …, 2023 - academic.oup.com
Background Antimicrobial susceptibility testing (AST) is not routinely performed for
Clostridioides difficile and data evaluating minimum inhibitory concentrations (MICs) are …

Clostridioides difficile resistance to antibiotics, including post-COVID-19 data

L Boyanova, G Dimitrov, R Gergova… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Updating data on Clostridioides difficile antibiotic resistance is
important for treatment improvement of C. difficile infections (CDIs). Areas covered Results …

Emerging antimicrobial resistance

CE Flynn, J Guarner - Modern Pathology, 2023 - Elsevier
The burden of emerging antimicrobial resistance (AMR) in the United States is significant
and even greater worldwide. Mitigation efforts have decreased the incidence and deaths …

Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences

B Kolte, U Nübel - Journal of Antimicrobial Chemotherapy, 2024 - academic.oup.com
Objectives To determine the frequencies and clonal distributions of putative genetic
determinants of resistance to antimicrobials applied for treatment of Clostridioides difficile …

Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China

X Li, Y Wang, R Cao, F Xiao, X Wang, L Ye… - Infection and Drug …, 2024 - Taylor & Francis
Background Our previous study reported a high rate of recurrence in children with
Clostridioides difficile (C. difficile) infection (CDI) after conventional antibiotic therapy. Here …

Are Vancomycin Non-Susceptible Clostridioides difficile Strains Emerging?

JD Lutgring, SL McKay, AS Gargis… - Clinical Infectious …, 2022 - academic.oup.com
TO THE EDITOR—We thank Chang et al [1] for their interest in our work [2] and the
recommendations. Regarding the issues they raised, we would like to take this opportunity …

Prevalence, genetic characteristics, and antimicrobial resistance of Clostridioides difficile isolates from horses in Korea

YR Lee, K Lee, JW Byun, H Kim, BJ So, BK Ku, HY Kim… - Anaerobe, 2023 - Elsevier
Objectives Clostridioides difficile is an etiological agent of enteric diseases in humans and
animals. Animals are considered a potential reservoir due to the genetic and antimicrobial …

Influence of binary toxin gene detection and decreased susceptibility to antibiotics among Clostridioides difficile strains on disease severity: a single-center study

DVS Costa, NVS Pham, RA Hays… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is the fifth leading cause of death from nonmalignant
gastrointestinal disease in the United States. The contribution of resistance to C. difficile …