Some of the most prominent and promising catalysts in organic synthesis for the requisite
construction of C–C and C–N bonds are palladium (Pd) catalysts, which play a pivotal role in …

Methods to functionalize arenes and heteroarenes in a site-selective manner are highly
sought after for rapidly constructing value-added molecules of medicinal, agrochemical, and …

This Perspective describes general methods for the preparation of polyfunctional zinc
organometallics and their use in Negishi cross-coupling reactions. Recent advances …

Azine‐containing biaryls are ubiquitous scaffolds in many areas of chemistry, and efficient
methods for their synthesis are continually desired. Pyridine rings are prominent amongst …

Parallel library synthesis is an important tool for drug discovery because it enables the
synthesis of closely related analogues in parallel via robust and general synthetic …

This report describes the chemoselective coupling of polyfluoroarenes with aryl germanes in
the presence of aromatic C–I, C–Br, C–Cl, C–OTf, and C–SiMe3 groups, as well as …

A palladium-catalyzed domino C–N coupling/Cacchi reaction is reported. Design of
photoluminescent bis-heterocycles, aided by density functional theory calculations, was …

New approaches to the Pd-catalysis employing palladacycle precatalysts have been
recently developed. Breakthroughs in this area using 2-aminobiphenyl palladacycle …

The Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles using
precatalysts P1 or P2 is reported. The procedure allows for the reaction of variously …

In situ generated catalysts and preformed catalysts are two practical strategies widely used
in cross-coupling methodology that have long been considered to involve the same active …