Nucleolytic ribozymes utilize general acid‐base catalysis to perform phosphodiester
cleavage. In most ribozyme classes, a conserved active site guanosine is positioned to act …

RNA structure is crucial to a wide range of cellular processes. The intimate relationship
between macromolecular structure and function necessitates the determination of high …

Pistol ribozyme (Psr) is a distinct class of small endonucleolytic ribozymes, which are
important experimental systems for defining fundamental principles of RNA catalysis and …

Catalytic RNAs or ribozymes are considered to be central to primordial biology. Most
ribozymes require moderate to high concentrations of divalent cations such as Mg2+ to fold …

While catalytic reactions of biomolecular processes play an indispensable role in life,
extracting the underlying molecular picture often remains challenging. Based on ab initio …

The accumulated material in evolutionary biology, greatly enhanced by the achievements of
modern synthetic biology, allows us to envision certain key hypothetical stages of prebiotic …

The 10–23 DNAzyme, a catalytic DNA molecule with RNA-cleaving activity, has garnered
significant interest for its potential therapeutic applications as a gene-silencing agent …

Varkud satellite ribozyme (VS ribozyme) is a class of catalytic RNA with self-cleavage
activity. The wild-type VS ribozyme has structural modularity with a relatively large catalytic …