Modeling Parkinson's disease with the alpha-synuclein protein
M Gómez-Benito, N Granado, P García-Sanz… - Frontiers in …, 2020 - frontiersin.org
Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …
Amyloid assembly and disassembly
E Chuang, AM Hori, CD Hesketh… - Journal of Cell …, 2018 - journals.biologists.com
Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …
α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B
DG Ferreira, M Temido-Ferreira… - Nature …, 2017 - nature.com
Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …
α‐Synuclein oligomers and clinical implications for Parkinson disease
Protein aggregation within the central nervous system has been recognized as a defining
feature of neurodegenerative diseases since the early 20th century. Since that time, there …
feature of neurodegenerative diseases since the early 20th century. Since that time, there …
Alpha-synuclein: from secretion to dysfunction and death
O Marques, TF Outeiro - Cell death & disease, 2012 - nature.com
The aggregation, deposition, and dysfunction of alpha-synuclein (aSyn) are common events
in neurodegenerative disorders known as synucleinopathies. These include Parkinson's …
in neurodegenerative disorders known as synucleinopathies. These include Parkinson's …
Curcumin modulates α-synuclein aggregation and toxicity
In human beings, Parkinson's disease (PD) is associated with the oligomerization and
amyloid formation of α-synuclein (α-Syn). The polyphenolic Asian food ingredient curcumin …
amyloid formation of α-synuclein (α-Syn). The polyphenolic Asian food ingredient curcumin …
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation
MJ Diógenes, RB Dias, DM Rombo… - Journal of …, 2012 - Soc Neuroscience
Parkinson's disease (PD) is the most common representative of a group of disorders known
as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various …
as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various …
Alpha synuclein: neurodegeneration and inflammation
G Forloni - International journal of molecular sciences, 2023 - mdpi.com
Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …
The role of Ca2+ signaling in Parkinson's disease
SV Zaichick, KM McGrath… - Disease models & …, 2017 - journals.biologists.com
Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells
to respond and adapt to constantly changing environments. In multicellular organisms, it …
to respond and adapt to constantly changing environments. In multicellular organisms, it …
Strategies for the treatment of Parkinson's disease: beyond dopamine
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …