Systemic autoimmune diseases are a group of disorders characterized by a failure in self-
tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these …

Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and
painless manner for patients has remained a central focus of next-generation diabetes …

Diabetic kidney disease remains the most common cause of end-stage kidney disease in
the world. Despite reductions in incidence rates of myocardial infarction and stroke in people …

Diabetes is currently a growing concern of the age. Prevention and treatment of diabetes is a
global health priority. Adiponectin is an adipocyte derived protein hormone that enhances …

OBJECTIVE Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on
circulating glycoproteins, and these alterations may be linked with diabetic kidney disease …

Clinical studies have reported associations between serum uric acid levels and the
development of diabetic nephropathy, but the underlying mechanisms remain elusive. There …

Diabetic kidney disease (DKD) is a major complication for diabetic patients. Adiponectin is
an insulin sensitizer and anti-inflammatory adipokine and is mainly secreted by adipocytes …

Aims Despite guideline-recommended treatments, including renin angiotensin system
inhibition, up to 40% of individuals with type 1 diabetes develop chronic kidney disease …

Cardiovascular disease remains the leading cause of mortality in patients with type 1
diabetes. Although cardiovascular disease complications are rare until adulthood, pathology …

Studies have demonstrated that protease-activated receptors (PARs) with four subtypes
(PAR1-4) are mainly expressed in the renal epithelial, endothelial, and podocyte cells …