Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously
reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate …

Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk
factor for the development of liver pathologies that can progress from hepatic steatosis …

Acetaminophen (APAP) is the most commonly used over-the-counter medication throughout
the world. At therapeutic doses, APAP has potent analgesic and antipyretic effects. The …

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its
prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 …

Acetaminophen (APAP) overdose can induce acute liver injury (ALI) with significant
morbidity and mortality. Propacetamol is an APAP prodrug, which is clinically bioequivalent …

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. Schisandra fructus is widely-used traditional Chinese medicine which possesses …

Currently, drug-induced liver injury caused by acetaminophen (APAP) is the second leading
cause of human liver transplantation. The only clinical antidote treatment for APAP-induced …

Background and Purpose Currently, ursodeoxycholic acid and obeticholic acid are the only
two FDA‐approved drugs for cholestatic liver diseases. Thus, new therapeutic approaches …

Schisandra sphenanthera is widely used as a tonic and restorative in many countries to
enhance the function of liver and other organs. Wuzhi tablet (WZ) is a preparation of an …

Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.
Wuzhi Tablet (WZ), a preparation of extract from Schisandra sphenanthera that is a …