Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter
and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the …

Though a multi-facetted disorder, Parkinson's disease is prototypically characterized by
neurodegeneration of nigrostriatal dopaminergic neurons of the substantia nigra pars …

Tourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and
abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc) …

Microglia mediate neuroinflammation and regulate brain development and homeostasis.
Microglial abnormalities are implicated in a range of neuropsychiatric pathology, including …

Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate
the immune system, but is also acting as a neurotransmitter. Histaminergic neurons project …

Prepulse inhibition (PPI) of the startle reflex is disrupted in a number of developmental
neuropsychiatric disorders, including Tourette syndrome (TS). This disruption is …

Network-oriented analysis is essential to identify those parts of a cell affected by a given
perturbation. The effect of neurodegenerative perturbations in the form of diseases of brain …

Aberrant histaminergic function has been proposed as a cause of tic disorders. A rare
mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has …

The histamine H3 receptor (H3R) is highly enriched in the spiny projection neurons (SPNs)
of the striatum, in both the D1 receptor (D1R)–expressing and D2 receptor (D2R) …

The basal ganglia have a central role in motor patterning, habits, motivated behaviors, and
cognition as well as in numerous neuropsychiatric disorders. Receptors for histamine …