Long-chain polyunsaturated fatty acids (LCPUFAs) and their metabolites are considered
essential factors to support bone and joint health. The n-6 PUFAs suppress the osteoblasts …

Excess adiposity in childhood may affect bone development, ultimately leading to bone
frailty. Previous reports showing an increased rate of extremity fractures in children with …

Accumulating evidence supports a complex relationship between adiposity and
osteoporosis in overweight/obese individuals, with local interactions and endocrine …

Bone metabolism is a lifelong process that includes bone formation and resorption.
Osteoblasts and osteoclasts are the predominant cell types associated with bone …

Bone is a dynamic tissue and is constantly being remodeled by bone cells. Metabolic
reprogramming plays a critical role in the activation of these bone cells and skeletal …

N-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and were considered
useful for the treatment of rheumatoid arthritis (RA). Recently, several studies suggested that …

Infancy and adolescence are crucial periods for bone health, since they are characterized by
intense physical growth and bone development. The unsatisfactory acquisition of bone mass …

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that has a range of positive impacts
on human health, including anti-inflammatory effects and inhibition of osteoclast formation …

Background: Bone health relies on the equilibrium between resorption and new bone
generation. Postmenopausal osteoporosis depends on estrogen deficiency which favorite …

Age-related bone loss is inevitable in both men and women and there will soon be more
people of extreme old age than ever before. Osteoporosis is a common chronic disease and …