Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

Conspectus Enolate alkylation and conjugate addition into an α, β-unsaturated system have
served as long-standing strategic disconnections for the installation of α-or β-substituents on …

Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward
approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF …

Dehydrogenative transformations of alkyl chains to alkenes through methylene carbon-
hydrogen (C–H) activation remain a substantial challenge. We report two classes of pyridine …

Catalyst-controlled site-selective activation of β-and γ-methylene carbon-hydrogen (C–H)
bonds of free carboxylic acids is a long-standing challenge. Here we show that, with a pair of …

Herein, we report a Ni-catalyzed C (sp2)–H hydroxylation of aryl bromides with N2O as an
oxygen-atom donor. The reaction is enabled by a 1, 4-Ni translocation that results in …

With the large number of Pd (II)-catalyzed C–H activation reactions of native substrates
developed in the past decade, the development of catalysts to enable the use of green …

The functionalization of C–H bonds in organic molecules is one of the most direct
approaches for chemical synthesis. Recent advances in catalysis have allowed native …

Metal-hydride hydrogen atom transfer (MHAT) has emerged as a useful tool to form
quaternary carbons from alkenes via hydrofunctionalization. Methods to date that cross …

A photoexcited-nitroarene-mediated anaerobic C–H hydroxylation of aliphatic systems is
reported. The success of this reaction is due to the bifunctional nature of the photoexcited …