Lipoic acid is an essential cofactor for mitochondrial metabolism and is synthesized de novo
using intermediates from mitochondrial fatty-acid synthesis type II, S-adenosylmethionine …

The pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle by
converting pyruvate into acetyl-coenzyme A. PDHc encompasses three enzymatically active …

Oxo acid dehydrogenase complexes are important metabolic checkpoints functioning at the
intercept of sugar and amino acid degradation. This review presents a short summary of …

Abstract The RstA/RstB system is a bacterial two-component regulatory system consisting of
the membrane sensor, RstB and its cognate response regulator (RR) RstA. The RstA of …

We report the 2.4 Å crystal structure for lipoamide dehydrogenase encoded by lpdC from
Mycobacterium tuberculosis. Based on the Lpd structure and sequence alignment between …

Thermodynamic analysis of urea− biopolymer interactions and effects of urea on folding of
proteins and α-helical peptides shows that urea interacts primarily with polar amide surface …

Iron-inducible transcription of the ap65-1 gene in Trichomonas vaginalis involves at least
three Myb-like transcriptional factors (tv Myb1, tv Myb2 and tv Myb3) that differentially bind to …

Branched chain ketoacid dehydrogenase kinase (BCKDK) deficiency is a recently described
inherited neurometabolic disorder of branched chain amino acid (BCAA) metabolism …

The 2-oxoacid dehydrogenase complexes (ODHc) consist of multiple copies of three
enzyme components: E1, a 2-oxoacid decarboxylase; E2, dihydrolipoyl acyl-transferase; …

The folding of the α-helix domain hbSBD of the mammalian mitochondrial branched-chain α-
ketoacid dehydrogenase complex is studied by the circular dichroism technique in absence …