The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Cytokines are involved in intestinal homeostasis and pathological processes associated
with inflammatory bowel disease (IBD). The biological effects of cytokines, including several …

Chronic, low grade, sterile inflammation frequently accompanies aging and age-related
diseases. Cellular senescence is associated with the production of proinflammatory …

We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the
transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I …

The JAK (Janus kinase) family members serve essential roles as the intracellular signalling
effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine …

The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non‐
receptor protein tyrosine kinases. They are involved in cell growth, survival, development …

Since its discovery two decades ago, the activation of the Janus kinase/signal transducers
and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

Introduction: Although the etiology of inflammatory bowel diseases (IBD) remains unknown,
accumulating evidence suggests that the intestinal tissue damage in these disorders is due …

Males with X-linked severe combined immunodeficiency (XSCID) have defects in the
common cytokine receptor γ chain (γc) gene that encodes a shared, essential component of …