Recent improvements in experimental and computational techniques that are used to study
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …

Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

This study identifies and analyzes statistically significant overlaps between selective sweep
screens in anatomically modern humans and several domesticated species. The results …

Background Domesticated from gray wolves between 10 and 40 kya in Eurasia, dogs
display a vast array of phenotypes that differ from their ancestors, yet mirror other …

Precursor messenger RNA (pre-mRNA) splicing is catalyzed by an intricate
ribonucleoprotein complex called the spliceosome. Although the spliceosome is considered …

Somatic mutations in the spliceosome gene ZRSR2—located on the X chromosome—are
associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of …

The fast technological development, particularly single nucleotide polymorphism array, array-
comparative genomic hybridization, and whole exome sequencing, has led to the discovery …

Mutations in multiple genes of the growth hormone/IGF‐I axis have been identified in
syndromes marked by growth failure. However, no pathogenic human mutations have been …

Abstract The U12-dependent (minor) spliceosome excises a rare group of introns that are
characterized by a highly conserved 5′ splice site and branch point sequence. Several …

A kink-turn (K-turn) is a three-dimensional RNA structure that exists in all three primary
phylogenetic domains. In this study, we developed the RIP-PEN-seq method to identify the …