Small-cell lung cancer (SCLC) is a deadly tumour accounting for approximately 15% of lung
cancers and is pathologically, molecularly, biologically and clinically very different from other …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

In this Opinion article, we summarize how changes in DNA methylation occur during aging
in mammals and discuss examples of how such events may contribute to the aging process …

RAS proteins are essential components of signalling pathways that emanate from cell
surface receptors. Oncogenic activation of these proteins owing to missense mutations is …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon
which novel approaches to the management of thyroid cancer can be developed. A recent …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …