As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …

Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …

Loop-extrusion and phase-separation have been proposed as mechanisms that shape
chromosome spatial organization. It is unclear, however, how they perform relative to each …

Technology for measuring 3D genome topology is increasingly important for studying gene
regulation, for genome assembly and for mapping of genome rearrangements. Hi-C and …

The linear sequence of DNA provides invaluable information about genes and their
regulatory elements along chromosomes. However, to fully understand gene function and …

Structural maintenance of chromosomes (SMC) complexes are essential proteins found in
genomes of all cellular organisms. Essential functions of these proteins, such as mitotic …

To the Editor—Three-dimensional (3D) genomic structures are vital for gene regulation and
cell function1. High-throughput technologies based on chromosome conformation capture …

Highlights•Networks are a useful framework to study chromatin structure
datasets.•Chromatin networks can be used to visualize the 3D epigenome and integrate …

Genomic architecture appears to play crucial roles in health and a variety of diseases. How
nuclear structures reorganize over different timescales is elusive, partly because the tools …