Over the past decade, various liquid biopsy techniques have emerged as viable alternatives
to the analysis of traditional tissue biopsy samples. Such surrogate 'biopsies' offer numerous …

Cholangiocarcinomas (CCA) are a heterogeneous group of tumors that are classified as
intrahepatic, perihilar, or distal according to the anatomic location within the biliary tract …

Current evaluation of treatment response in solid tumors depends on dynamic changes in
tumor diameters as measured by imaging. However, these changes can only be detected …

Cholangiocarcinoma (CCA) is a fatal disease often detected late in unresectable stages.
Currently, there are no effective diagnostic methods or biomarkers to detect CCA early with …

Simple Summary We present an exhaustive review of the literature that has evaluated the
role of ctDNA analysis in upper gastrointestinal tumors, including gastroesophageal …

Biliary tract cancer (BTC) is an aggressive tumor characterized by a poor prognosis. In the
latest years, targetable genetic alterations have been discovered in BTC patients, leading to …

Biliary tract cancers are heterogeneous in etiology, morphology and molecular
characteristics thus impacting disease management. Diagnosis is complex and prognosis …

With the recent advances of next generation sequencing technologies, comprehensive
genomic profiling (CGP) tests, which are designed to measure more than hundreds of …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma
(dCCA) are very aggressive neoplasms. However, effective treatments are still limited …

Intrahepatic cholangiocarcinoma (iCCA) is the second most prevalent primary liver cancer.
Although the genetic characterization of iCCA has led to targeted therapies for treating …