In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …

Crosslinking of proteins has gained immense significance in the fabrication of biomaterials
for various health care applications. Various novel chemical-based strategies are being …

Protein–RNA interactions regulate RNA fate and function, and defects can lead to various
disorders. Such interactions have mainly been studied by nucleoside-based UV crosslinking …

Small molecule covalent drugs provide desirable therapeutic properties over noncovalent
ones for treating challenging diseases. The potential of covalent protein drugs, however …

Protein–carbohydrate interactions play important roles in various biological processes, such
as organism development, cancer metastasis, pathogen infection and immune response, but …

Genetically introducing novel chemical bonds into proteins provides innovative avenues for
biochemical research, protein engineering, and biotherapeutic applications. Recently, latent …

Interactions among biomacromolecules, predominantly noncovalent, underpin biological
processes. However, recent advancements in biospecific chemistry have enabled the …

Transmission of chemical information between cells and across lipid bilayer membranes is
of profound significance in many biological processes. The design of synthetic signalling …

Cellular senescence, a process that arrests the cell cycle, is a cellular response mechanism
for various stresses and is implicated in aging and various age-related diseases. However …

Conspectus Despite advances in genome sequencing technology, the complete molecular
interaction networks reflecting the biological functions of gene products have not been fully …