[HTML][HTML] Neuropathic pain: from mechanisms to treatment
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …
common chronic pain condition with major impact on quality of life. Examples include …
Brain circuits for pain and its treatment
Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …
Burn injury: challenges and advances in burn wound healing, infection, pain and scarring
Y Wang, J Beekman, J Hew, S Jackson… - Advanced drug delivery …, 2018 - Elsevier
Severe burn injuries are the most traumatic and physically debilitating injuries affecting
nearly every organ system and leading to significant morbidity and mortality. Early burn …
nearly every organ system and leading to significant morbidity and mortality. Early burn …
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …
House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation
N Serhan, L Basso, R Sibilano, C Petitfils… - Nature …, 2019 - nature.com
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe
itching and type 2 immunity-associated hypersensitivity to widely distributed allergens …
itching and type 2 immunity-associated hypersensitivity to widely distributed allergens …
A basophil-neuronal axis promotes itch
Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and
noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory …
noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory …
Sensory neurons that detect stretch and nutrients in the digestive system
Neural inputs from internal organs are essential for normal autonomic function. The vagus
nerve is a key body-brain connection that monitors the digestive, cardiovascular, and …
nerve is a key body-brain connection that monitors the digestive, cardiovascular, and …
Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and sensory neuroscience research
2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …
by comparing it with publicly available human and mouse RNA-seq data sets (sources …
Activation of mast-cell-expressed mas-related G-protein-coupled receptors drives non-histaminergic itch
J Meixiong, M Anderson, N Limjunyawong… - Immunity, 2019 - cell.com
Classical itch studies have focused on immunoglobulin E (IgE)-mediated mast cell activation
and histamine release. Recently, members of the Mas-related G-protein-coupled receptor …
and histamine release. Recently, members of the Mas-related G-protein-coupled receptor …
Protease-activated receptors in health and disease
CJ Peach, LE Edgington-Mitchell… - Physiological …, 2023 - journals.physiology.org
Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …
protease-activated receptors (PARs). The four known PARs are members of the large family …