Drug-like compounds are most of the time denied approval and use owing to the
unexpected clinical side effects and cross-reactivity observed during clinical trials. These …

Background In silico target prediction of compounds plays an important role in drug
discovery. The chemical similarity ensemble approach (SEA) is a promising method, which …

Complex diseases (eg, Alzheimer's disease) or infectious diseases are usually caused by
complicated and varied factors, including environmental and genetic factors. Multi-target …

Abstract Traditional Chinese Medicine (TCM) has a long history of widespread clinical
applications, especially in East Asia, and is becoming frequently used in Western countries …

Abstract As coronavirus disease 2019 (COVID-19) threatens human health globally,
infectious disorders have become one of the most challenging problem for the medical …

Introduction Small molecules often bind to multiple targets, a behavior termed
polypharmacology. Anticipating polypharmacology is essential for drug discovery since …

Metformin, an established first-line treatment for patients with type 2 diabetes, has been
associated with gastrointestinal (GI) adverse effects that limit its use. Histamine and …

As life expectancy increases, dementia affects a growing number of people worldwide.
Besides current treatments, phosphodiesterase 9 (PDE9) represents an alternative target for …

G protein-coupled receptors (GPCRs) are targets of many drugs, of which∼ 25% are
indicated for central nervous system (CNS) disorders. Drug promiscuity affects their efficacy …

Cyclic nucleotides viz., cAMP/cGMP has been well known to play important role in cellular
function and deficiency in their levels has been implicated in the pathogenesis of various …