Context Menopause, the permanent cessation of menses, reflects oocyte depletion and loss
of gonadal steroids. It is preceded by a transition state, the perimenopause, which is …

Every woman who lives past midlife will experience menopause, which, by definition, is
complete cessation of ovarian function. This process might occur spontaneously (natural …

Background Neurokinin 3 receptor antagonists are potential non-hormonal therapies for the
treatment of vasomotor symptoms in menopausal women as options are scarce for those …

Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …

OBJECTIVE: To evaluate the safety, tolerability, and effect of fezolinetant on endometrial
health over 52 weeks. METHODS: We conducted a phase 3, randomized, double-blind, 52 …

Importance Safe and effective nonhormonal treatments for menopausal vasomotor
symptoms (VMS) are needed. Objective To evaluate the efficacy and safety of elinzanetant …

Multiple changes occur across various endocrine systems as an individual ages. The
understanding of the factors that cause age-related changes and how they should be …

Hormone therapy (HT) is an effective treatment for menopausal symptoms, including
vasomotor symptoms and genitourinary syndrome of menopause. Randomized trials also …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

Four of 5 women experience psychological or physical symptoms around menopause, with
varying degrees of severity and disruption in their lives. 1 Clinicians and women normally …