Vascular endothelial cells: heterogeneity and targeting approaches
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …
Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets
SS Dhanisha, C Guruvayoorappan, S Drishya… - Critical reviews in …, 2018 - Elsevier
Mucins are the main structural components of mucus that create a selective protective
barrier for epithelial surface and also execute wide range of other physiological functions …
barrier for epithelial surface and also execute wide range of other physiological functions …
Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
SM Evrard, L Lecce, KC Michelis… - Nature …, 2016 - nature.com
Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …
Lactobacillus Adhesion to Mucus
MLV Tassell, MJ Miller - Nutrients, 2011 - mdpi.com
Mucus provides protective functions in the gastrointestinal tract and plays an important role
in the adhesion of microorganisms to host surfaces. Mucin glycoproteins polymerize, forming …
in the adhesion of microorganisms to host surfaces. Mucin glycoproteins polymerize, forming …
Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes
to compromised cardiac function and potentially heart failure. Cardiac pressure overload …
to compromised cardiac function and potentially heart failure. Cardiac pressure overload …
Tumour vascular targeting
D Neri, R Bicknell - Nature Reviews Cancer, 2005 - nature.com
It is now accepted that the growth of solid tumours is dependent on their capacity to acquire
a blood supply, and much effort has been directed towards the development of agents …
a blood supply, and much effort has been directed towards the development of agents …
Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process
K Kizhatil, M Ryan, JK Marchant, S Henrich… - PLoS …, 2014 - journals.plos.org
Schlemm's canal (SC) plays central roles in ocular physiology. These roles depend on the
molecular phenotypes of SC endothelial cells (SECs). Both the specific phenotype of SECs …
molecular phenotypes of SC endothelial cells (SECs). Both the specific phenotype of SECs …
Arterial versus venous endothelial cells
NG Dela Paz, PA D'Amore - Cell and tissue research, 2009 - Springer
Vascular endothelial cells (ECs) form the inner lining of all blood vessels from the largest
artery and veins, viz., the aorta and venae cavae, respectively, to the capillaries that connect …
artery and veins, viz., the aorta and venae cavae, respectively, to the capillaries that connect …
Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer
In search of redox mechanisms in breast cancer, we uncovered a striking role for glutathione
peroxidase 2 (GPx2) in oncogenic signaling and patient survival. GPx2 loss stimulates …
peroxidase 2 (GPx2) in oncogenic signaling and patient survival. GPx2 loss stimulates …
Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis
M Mashreghi, H Azarpara, MR Bazaz… - Journal of cellular …, 2018 - Wiley Online Library
Angiogenesis is known as one of the hallmarks in cancer which could play a key role in
providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow …
providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow …