Review on Alzheimer's disease: inhibition of amyloid beta and tau tangle formation
It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …
Dementia is a group of symptoms that affect neurons and cause some mental disorders …
Rationally designed peptides and peptidomimetics as inhibitors of amyloid-β (Aβ) aggregation: Potential therapeutics of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …
Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts
K Hosseinpour‐Moghaddam… - Journal of cellular …, 2018 - Wiley Online Library
The balance between synthesis and degradation is crucial to maintain cellular homeostasis
and different mechanisms are known to keep this balance. In this review, we will provide a …
and different mechanisms are known to keep this balance. In this review, we will provide a …
Poly (trehalose) nanoparticles prevent amyloid aggregation and suppress polyglutamine aggregation in a Huntington's disease model mouse
Prevention and therapeutic strategies for various neurodegenerative diseases focus on
inhibiting protein fibrillation, clearing aggregated protein plaques from the brain, and …
inhibiting protein fibrillation, clearing aggregated protein plaques from the brain, and …
Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects
J Li, W Liao, D Huang, M Ou, T Chen, X Wang… - Coordination Chemistry …, 2023 - Elsevier
Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …
behavioral disturbance and progressive cognitive impairment, and it is common in pre …
Supramolecular copolymers of peptides and lipidated peptides and their therapeutic potential
Supramolecular peptide chemistry offers a versatile strategy to create chemical systems
useful as new biomaterials with potential to deliver nearly 1000 known candidate peptide …
useful as new biomaterials with potential to deliver nearly 1000 known candidate peptide …
Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer's Disease?
G Di Natale, G Sabatino, MFM Sciacca, R Tosto… - Molecules, 2022 - mdpi.com
In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …
assemblies in the brain, has been considered the mainstream concept sustaining research …
Trehalose against Alzheimer's disease: insights into a potential therapy
Trehalose is a natural disaccharide with a remarkable ability to stabilize biomolecules. In
recent years, trehalose has received growing attention as a neuroprotective molecule and …
recent years, trehalose has received growing attention as a neuroprotective molecule and …
Rationally designed peptidomimetic modulators of Aβ toxicity in Alzheimer's disease
Alzheimer's disease is one of the devastating illnesses mankind is facing in the 21st century.
The main pathogenic event in Alzheimer's disease is believed to be the aggregation of the β …
The main pathogenic event in Alzheimer's disease is believed to be the aggregation of the β …
Peptides, peptidomimetics, and carbohydrate–peptide conjugates as amyloidogenic aggregation inhibitors for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder accounting for 60–
80% of dementia cases. For many years, AD causality was attributed to amyloid-β (Aβ) …
80% of dementia cases. For many years, AD causality was attributed to amyloid-β (Aβ) …