The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

Background and Purpose The growing epidemic of obesity and metabolic diseases
necessitates the development of novel strategies to prevent and treat such diseases. Current …

Mounting evidence highlights the role of adipose tissue in the development of a systemic
inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular …

The dramatic increase in the prevalence of obesity and its strong association with
cardiovascular disease have resulted in unprecedented interest in understanding the effects …

Adipose tissue is an enormously active endocrine organ, secreting various hormones, such
as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor …

Introduction Inflammation contributes to cardiovascular disease and is exacerbated with
increased adiposity, particularly omental adiposity; however, the role of epicardial fat is …

Results: CAP antagonized high-fat diet (HFD)-induced obesity without decreasing energy
intake in mice. HFD suppressed TRPV1 expression and activity in BAT and CAP countered …

Leptin, a 167-amino acid peptide hormone produced by white adipose tissue, is primarily
involved in the regulation of food intake and energy expenditure. Leptin receptors are …

Nesfatin-1 is a novel satiety molecule in the hypothalamus and is also present in peripheral
tissues. Here we sought to identify the active segment of nesfatin-1 and to determine the …