The gut microbiome alterations and inflammation-driven pathogenesis of Alzheimer's disease—a critical review

M Sochocka, K Donskow-Łysoniewska, BS Diniz… - Molecular …, 2019 - Springer
One of the most important scientific discoveries of recent years was the disclosure that the
intestinal microflora takes part in bidirectional communication between the gut and the brain …

[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease

J Nowell, E Blunt, D Gupta, P Edison - Ageing Research Reviews, 2023 - Elsevier
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Microbiota modulation counteracts Alzheimer's disease progression influencing neuronal proteolysis and gut hormones plasma levels

L Bonfili, V Cecarini, S Berardi, S Scarpona… - Scientific reports, 2017 - nature.com
Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through
the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the …

SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model

L Bonfili, V Cecarini, M Cuccioloni, M Angeletti… - Molecular …, 2018 - Springer
The gut-brain axis is a bidirectional communication network functionally linking the gut and
the central nervous system (CNS). Based on this, the rational manipulation of intestinal …

The immunopathogenesis of Alzheimer's disease is related to the composition of gut microbiota

F Leblhuber, D Ehrlich, K Steiner, S Geisler, D Fuchs… - Nutrients, 2021 - mdpi.com
The microbiota–gut–brain axis plays an important role in the development of
neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence …

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer's disease

V de JR De-Paula, AS Forlenza, OV Forlenza - Pharmacological research, 2018 - Elsevier
Approximately 95% of the symbiotic microbes in human body are located in the gut. This
microbioma is involved in important homeostatic processes, not only related to …

Microbiota modulation as preventative and therapeutic approach in Alzheimer's disease

L Bonfili, V Cecarini, O Gogoi, C Gong… - The FEBS …, 2021 - Wiley Online Library
The gut microbiota coevolves with its host, and numerous factors like diet, lifestyle, drug
intake and geographical location continuously modify its composition, deeply influencing …

Multiple roles of short-chain fatty acids in Alzheimer disease

H Chen, L Meng, L Shen - Nutrition, 2022 - Elsevier
Alzheimer disease (AD) is the most common form of neurodegenerative disease in older
adults and has a complicated etiology. Recently, the roles of short-chain fatty acids (SCFAs) …

Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

JR Clarke, NM Lyra e Silva, CP Figueiredo… - EMBO molecular …, 2015 - embopress.org
Alzheimer's disease (AD) is associated with peripheral metabolic disorders. Clinical/
epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that …

Role of metabolism in neurodegenerative disorders

C Procaccini, M Santopaolo, D Faicchia, A Colamatteo… - Metabolism, 2016 - Elsevier
Along with the increase in life expectancy over the last century, the prevalence of age-
related disorders, such as neurodegenerative diseases continues to rise. This is the case of …