One of the hallmarks of malignant cell populations is the ability to undergo continuous
proliferation. This property allows clonal lineages to acquire sequential aberrations that can …

The function of many eukaryotic proteins is regulated by highly dynamic changes in their
nucleocytoplasmic distribution. The ability to precisely and reversibly control nuclear …

According to the prevailing 'clock'model, chromosome decondensation and nuclear
envelope reformation when cells exit mitosis are byproducts of Cdk1 inactivation at the …

Objective: We aim to enhance the effectiveness of curcumin analog PGV-1 through co-
treatment with diosmin, a citrus flavonoid, on 4T1 cells and evaluate the molecular targets …

Cdh1, a coactivator of the anaphase-promoting complex (APC), is a potential tumor
suppressor. Cdh1 ablation promotes precocious S-phase entry, but it was unclear how this …

Eukaryotic organisms use conserved checkpoint mechanisms that regulate Cdk1 by
inhibitory phosphorylation to prevent mitosis from interfering with DNA replication or repair …

Hypermethylation of SOCS genes is associated with many human cancers, suggesting a
role as tumor suppressors. As adaptor molecules for ubiquitin ligases, SOCS proteins …

The DNA damage checkpoint, when activated in response to genotoxic damage during S
phase, arrests cells in G2 phase of the cell cycle. ATM, ATR, Chk1 and Chk2 kinases are the …

Abstract Cyclin-dependent kinase 1 (Cdk1) controls cell proliferation and is inhibited by
promising anticancer agents, but its mode of action and the consequences of its inhibition …

Extensive experimental evidence has been demonstrated that the dynamics of CDK1‐APC
feedback loop play crucial roles in regulating cell cycle processes, but the dynamical …