Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii

M Hamidian, SJ Nigro - Microbial genomics, 2019 - microbiologyresearch.org
Acinetobacter baumannii is a nosocomial pathogen that has emerged as a global threat
because of high levels of resistance to many antibiotics, particularly those considered to be …

Critical analysis of antibacterial agents in clinical development

U Theuretzbacher, K Bush, S Harbarth… - Nature Reviews …, 2020 - nature.com
The antibacterial agents currently in clinical development are predominantly derivatives of
well-established antibiotic classes and were selected to address the class-specific …

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections

B Isler, Y Doi, RA Bonomo… - Antimicrobial agents and …, 2019 - Am Soc Microbiol
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen
causing substantial morbidity and mortality. Current treatment options for CRAB are limited …

Aminoglycoside resistance: the emergence of acquired 16S ribosomal RNA methyltransferases

Y Doi, J Wachino, Y Arakawa - Infectious Disease Clinics, 2016 - id.theclinics.com
Antimicrobial resistance has been recognized as one of the most pressing public health and
societal issues of our times. The problem is most acute in gram-negative bacteria, where …

Identification of Acinetobacter baumannii loci for capsular polysaccharide (KL) and lipooligosaccharide outer core (OCL) synthesis in genome assemblies using curated …

KL Wyres, SM Cahill, KE Holt, RM Hall… - Microbial …, 2019 - microbiologyresearch.org
Multiply antibiotic-resistant Acinetobacter baumannii infections are a global public health
concern and accurate tracking of the spread of specific lineages is needed. Variation in the …

Whole genome sequencing in clinical and public health microbiology

JC Kwong, N McCallum, V Sintchenko, BP Howden - Pathology, 2015 - Elsevier
Genomics and whole genome sequencing (WGS) have the capacity to greatly enhance
knowledge and understanding of infectious diseases and clinical microbiology. The growth …

Resources for genetic and genomic analysis of emerging pathogen Acinetobacter baumannii

LA Gallagher, E Ramage, EJ Weiss… - Journal of …, 2015 - Am Soc Microbiol
Acinetobacter baumannii is a Gram-negative bacterial pathogen notorious for causing
serious nosocomial infections that resist antibiotic therapy. Research to identify factors …

Potential reservoirs of antimicrobial resistance in livestock waste and treated wastewater that can be disseminated to agricultural land

AM Ibekwe, AS Bhattacharjee, D Phan… - Science of The Total …, 2023 - Elsevier
Livestock manure, dairy lagoon effluent, and treated wastewater are known reservoirs of
antibiotic resistance genes (ARGs), antibiotic-resistant bacteria (ARB), and virulence factor …

The Genomic Diversification of the Whole Acinetobacter Genus: Origins, Mechanisms, and Consequences

M Touchon, J Cury, EJ Yoon, L Krizova… - Genome biology and …, 2014 - academic.oup.com
Bacterial genomics has greatly expanded our understanding of microdiversification patterns
within a species, but analyses at higher taxonomical levels are necessary to understand and …