Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus

AA Adeniji, KE Knoll, DT Loots - Applied microbiology and biotechnology, 2020 - Springer
The latest WHO report estimates about 1.6 million global deaths annually from TB, which is
further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV …

The medicinal chemistry of chalcones as anti-Mycobacterium tuberculosis agents

CN Rodrí guez-Silva, IM Prokopczyk… - Mini Reviews in …, 2022 - ingentaconnect.com
Tuberculosis (TB), a highly fatal infectious disease, is caused by Mycobacterium
tuberculosis (Mtb) that has inflicted mankind for several centuries. In 2019, the staggering …

In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis

KE Knoll, MM van der Walt, DT Loots - Microbiology Spectrum, 2022 - Am Soc Microbiol
The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics
and the high costs for clinical trials, hampers the development of novel antimicrobial agents …

Synthesis, characterization and utility of a series of novel copper (II) complexes as excellent surface disinfectants against nosocomial infections

N Kushwaha, S Negi, A Kumar, E Zangrando… - Dalton …, 2021 - pubs.rsc.org
Nosocomial infections are among the major public health concerns, especially during the
ongoing Covid19 pandemic. There is a great demand for novel chemical agents that are …

Recent Developments in Nanocatalyzed Green Synthetic Protocols of Biologically Potent Diverse O-Heterocycles—A Review

S Kumar, B Saroha, G Kumar, E Lathwal, S Kumar… - Catalysts, 2022 - mdpi.com
The dynamic growth in green organic synthetic methodologies for diverse heterocyclic
scaffolds has substantially contributed to the field of medicinal chemistry over the last few …

Novel quinoline-piperazine hybrids: the design, synthesis and evaluation of antibacterial and antituberculosis properties

K Gnanavelu, VK KS, S Eswaran… - RSC Medicinal …, 2023 - pubs.rsc.org
A communicable disease such as tuberculosis (TB), which takes∼ 10 million lives
worldwide every year, is one of the major concerns for future generations. The intake of …

Modulators targeting protein-protein interactions in Mycobacterium tuberculosis

G Luo, T Ming, L Yang, L He, T Tao, Y Wang - Microbiological Research, 2024 - Elsevier
Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M.
tuberculosis), mainly transmitted through droplets to infect the lungs, and seriously affecting …

Ultrasounds-mediated 10-seconds synthesis of chalcones as potential farnesyltransferase inhibitors

G Homerin, AS Nica, A Farce, J Dubois… - Bioorganic & Medicinal …, 2020 - Elsevier
A broad range of chalcones and derivatives were easily and rapidly synthesized, following
Claisen-Schmidt condensation of (hetero) aryl ketones and (hetero) aryl aldehydes using a …

An expedient, one-pot, stepwise sequential approach for the regioselective synthesis of pyrazolines

S Ganesan, M Sarangapani… - Journal of Chemical …, 2021 - journals.sagepub.com
An efficient approach for the synthesis of pyrazoline/pyrazole-tethered pyridinyl methanones
is described via a one-pot, stepwise, sequential methodology using chalcones and pyridine …

Synthetic approaches to potent heterocyclic inhibitors of tuberculosis: A decade review

U Dasmahapatra, K Chanda - Frontiers in Pharmacology, 2022 - frontiersin.org
Tuberculosis (TB) continues to be a significant global health concern with about 1.5 million
deaths annually. Despite efforts to develop more efficient vaccines, reliable diagnostics, and …