Virtual screening web servers: designing chemical probes and drug candidates in the cyberspace

N Singh, L Chaput, BO Villoutreix - Briefings in bioinformatics, 2021 - academic.oup.com
The interplay between life sciences and advancing technology drives a continuous cycle of
chemical data growth; these data are most often stored in open or partially open databases …

Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development

P Pandey, JS Rane, A Chatterjee, A Kumar… - Journal of …, 2021 - Taylor & Francis
Spike glycoprotein, a class I fusion protein harboring the surface of SARS-CoV-2 (SARS-
CoV-2S), plays a seminal role in the viral infection starting from recognition of the host cell …

Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants – Withania somnifera (Ashwagandha), Tinospora cordifolia …

P Shree, P Mishra, C Selvaraj, SK Singh… - Journal of …, 2022 - Taylor & Francis
Abstract COVID-19 (Coronavirus disease 2019) is a transmissible disease initiated and
propagated through a new virus strain SARS-CoV-2 (Severe Acute Respiratory Syndrome …

[HTML][HTML] Pesticide informatics expands the opportunity for structure-based molecular design and optimization

W Zhao, Y Huang, GF Hao - Advanced Agrochem, 2022 - Elsevier
The discovery process of pesticides is confronting more and more difficult obstacles,
including the rising costs of materials and labor, which are costly and time-consuming …

[PDF][PDF] Makara Journal of Scienc e

RM Wijaya, MA Hafidzhah, VD Kharisma… - Makara Journal of …, 2021 - researchgate.net
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide pandemic …

Molecular docking of phytochemicals targeting GFRs as therapeutic sites for cancer: an in silico study

LE Mendie, S Hemalatha - Applied biochemistry and biotechnology, 2022 - Springer
Drug delivery in a safe manner is a major challenge in the drug development process.
Growth factor receptors (GFRs) are known to have profound roles in the growth and …

Mechanism of gating and partial agonist action in the glycine receptor

J Yu, H Zhu, R Lape, T Greiner, J Du, W Lü, L Sivilotti… - Cell, 2021 - cell.com
Ligand-gated ion channels mediate signal transduction at chemical synapses and transition
between resting, open, and desensitized states in response to neurotransmitter binding …

DeepBindRG: a deep learning based method for estimating effective protein–ligand affinity

H Zhang, L Liao, KM Saravanan, P Yin, Y Wei - PeerJ, 2019 - peerj.com
Proteins interact with small molecules to modulate several important cellular functions. Many
acute diseases were cured by small molecule binding in the active site of protein either by …

Charge disproportionate molecular redox for discrete memristive and memcapacitive switching

S Goswami, SP Rath, D Thompson, S Hedström… - Nature …, 2020 - nature.com
Electronic symmetry breaking by charge disproportionation results in multifaceted changes
in the electronic, magnetic and optical properties of a material, triggering ferroelectricity …

In silico Prediction, Characterization, Molecular Docking, and Dynamic Studies on Fungal SDRs as Novel Targets for Searching Potential Fungicides Against …

M Aamir, VK Singh, MK Dubey, M Meena… - Frontiers in …, 2018 - frontiersin.org
Vascular wilt of tomato caused by Fusarium oxysporum f. sp. lycopersici (FOL) is one of the
most devastating diseases, that delimits the tomato production worldwide. Fungal short …