[HTML][HTML] Ionizing radiation and complex DNA damage: quantifying the radiobiological damage using Monte Carlo simulations

KP Chatzipapas, P Papadimitroulas, D Emfietzoglou… - Cancers, 2020 - mdpi.com
Ionizing radiation is a common tool in medical procedures. Monte Carlo (MC) techniques are
widely used when dosimetry is the matter of investigation. The scientific community has …

[HTML][HTML] Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates

Y Matsuya, SJ McMahon, K Tsutsumi, K Sasaki… - Scientific reports, 2018 - nature.com
During exposure to ionizing radiation, sub-lethal damage repair (SLDR) competes with DNA
damage induction in cultured cells. By virtue of SLDR, cell survival increases with decrease …

Modeling of yield estimation for DNA strand breaks based on Monte Carlo simulations of electron track structure in liquid water

Y Matsuya, T Kai, Y Yoshii, Y Yachi, S Naijo… - Journal of Applied …, 2019 - pubs.aip.org
DNA strand breaks are induced in cells mainly composed of liquid water along ionizing
radiation tracks. For estimating DNA strand break yields, track structures for electrons in …

Microdosimetric calculations of the direct DNA damage induced by low energy electrons using the Geant4-DNA Monte Carlo code

S Margis, M Magouni, I Kyriakou… - Physics in Medicine …, 2020 - iopscience.iop.org
To calculate the yield of direct DNA damage induced by low energy electrons using Monte
Carlo generated microdosimetric spectra at the nanometer scale and examine the influence …

[HTML][HTML] Microdosimetry and dose-averaged LET calculations of protons in liquid water: a novel geant4-DNA application

A Baratto-Roldán, A Bertolet, G Baiocco… - Frontiers in …, 2021 - frontiersin.org
The spatial distribution of energy deposition events is an essential aspect in the
determination of the radiobiological effects of ionizing radiation at the cellular level …

Investigation of the anisotropic distribution of microdosimetric quantities in the vicinity of X-ray-irradiated gold nanoparticles

J Derrien, N Pauly, JF Adam, B Reniers - Radiation Physics and Chemistry, 2023 - Elsevier
High-Z nanoparticles incorporated in tumors have great potential to enhance radiotherapy
treatments by increasing the absorbed radiation dose in the vicinity of the nanoparticle …

A simulation approach for determining the spectrum of DNA damage induced by protons

M Mokari, MH Alamatsaz, H Moeini… - Physics in Medicine & …, 2018 - iopscience.iop.org
To study the molecular damage induced in the form of single-strand and double-strand
breaks by ionizing radiation at the DNA level, the Geant4-DNA Monte Carlo simulation code …

Microdosimetric evaluation of current and alternative brachytherapy sources—a Geant4-DNA simulation study

G Famulari, P Pater, SA Enger - International Journal of Radiation …, 2018 - Elsevier
Purpose Radioisotopes such as 75 Se, 169 Yb, and 153 Gd have photon energy spectra
and half-lives that make them excellent candidates as alternatives to 192 Ir for high-dose …

Dose‐averaged LET calculation for proton track segments using microdosimetric Monte Carlo simulations

A Bertolet, A Baratto‐Roldán, S Barbieri… - Medical …, 2019 - Wiley Online Library
Purpose There is an increasing interest in calculating linear energy transfer (LET)
distributions for proton therapy treatments in order to assess the influence of this quantity in …

[HTML][HTML] The impact of dose rate on responses of human lens epithelial cells to ionizing irradiation

Y Matsuya, T Sato, Y Yachi, H Date, N Hamada - Scientific Reports, 2024 - nature.com
The knowledge on responses of human lens epithelial cells (HLECs) to ionizing radiation
exposure is important to understand mechanisms of radiation cataracts that are of concern in …