Mitochondria have diverse functions critical to whole-body metabolic homeostasis.
Endurance training alters mitochondrial activity, but systematic characterization of these …

Regular exercise has many physical and brain health benefits, yet the molecular
mechanisms mediating exercise effects across tissues remain poorly understood. Here we …

The molecular mechanisms behind the potential 'anti-aging'effects of exercise remain to be
elucidated. Janssens et al. studied the lipidome of different mouse tissues and human …

Exercise has multiple beneficial effects on human metabolic health and is regarded as a
“polypill” for various diseases. At present, the lack of physical activity usually causes an …

Transcriptomics is a powerful tool for unraveling the molecular effects of genetic variants and
disease diagnosis. Prior studies have demonstrated that choice of genome build impacts …

Objectives In this investigation, we addressed the contribution of the core circadian clock
factor, BMAL1, in skeletal muscle to both acute transcriptional responses to exercise and …

Feature into a six-year study of people and rats that aims to create a comprehensive map of
the molecules behind the effects of exercise, and how they change during and after a …

Background: There is growing consensus in favor of returning individual specific research
results that are clinically actionable, valid, and reliable. However, deciding what and how …

Although reduced representation bisulfite sequencing (RRBS) measures DNA methylation
(DNAme) across CpG-rich genomic regions with high sensitivity, the assay can be time …

INTRODUCTION: Skeletal muscle regulates central nervous system (CNS) function and
health, activating the muscle-to-brain axis through the secretion of skeletal muscle …