A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Elastic fibers: Formation, function, and fate during aging and disease

CEH Schmelzer, L Duca - The FEBS Journal, 2022 - Wiley Online Library
Elastic fibers are extracellular components of higher vertebrates and confer elasticity and
resilience to numerous tissues and organs such as large blood vessels, lungs, and skin …

Sialidase inhibitors with different mechanisms

JM Keil, GR Rafn, IM Turan, MA Aljohani… - Journal of medicinal …, 2022 - ACS Publications
Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …

Sialic acid metabolism as a potential therapeutic target of atherosclerosis

C Zhang, J Chen, Y Liu, D Xu - Lipids in health and disease, 2019 - Springer
Sialic acid (Sia), the acylated derivative of the nine-carbon sugar neuraminic acid, is a
terminal component of the oligosaccharide chains of many glycoproteins and glycolipids. In …

The role of elastin-derived peptides in human physiology and diseases

A Le Page, A Khalil, P Vermette, EH Frost, A Larbi… - Matrix Biology, 2019 - Elsevier
Once considered as inert, the extracellular matrix recently revealed to be biologically active.
Elastin is one of the most important components of the extracellular matrix. Many vital organs …

Impact of protein glycosylation on lipoprotein metabolism and atherosclerosis

A Pirillo, M Svecla, AL Catapano… - Cardiovascular …, 2021 - academic.oup.com
Protein glycosylation is a post-translational modification consisting in the enzymatic
attachment of carbohydrate chains to specific residues of the protein sequence. Several …

The elastin receptor complex: An emerging therapeutic target against age-related vascular diseases

D Tembely, A Henry, L Vanalderwiert… - Frontiers in …, 2022 - frontiersin.org
The incidence of cardiovascular diseases is increasing worldwide with the growing aging of
the population. Biological aging has major influence on the vascular tree and is associated …

Extracellular matrix: paving the way to the newest trends in atherosclerosis

C Gialeli, A Shami, I Gonçalves - Current opinion in lipidology, 2021 - journals.lww.com
Extracellular matrix: paving the way to the newest trends in... : Current Opinion in Lipidology
Extracellular matrix: paving the way to the newest trends in atherosclerosis : Current Opinion …

Polysialic acid in the immune system

TM Villanueva-Cabello… - Frontiers in …, 2022 - frontiersin.org
Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent
biophysical characteristics that when expressed drastically influences the interaction …

Prognostic value of elevated levels of plasma N-Acetylneuraminic acid in patients with heart failure

C Li, M Zhao, L Xiao, H Wei, Z Wen, D Hu… - Circulation: Heart …, 2021 - Am Heart Assoc
Background: Cardiac sialylation is involved in a variety of physiological processes in the
heart. Altered sialylation has been implicated in heart failure (HF) mice. However, its role in …