The role of reactive oxygen species and metabolism on cancer cells and their microenvironment

A Costa, A Scholer-Dahirel… - Seminars in cancer biology, 2014 - Elsevier
Compelling evidence show that reactive oxygen species (ROS) levels are finely regulated in
the cell and can act as “second messengers” in response to diverse stimuli. In tumor …

The antioxidative function of alpha‐ketoglutarate and its applications

S Liu, L He, K Yao - BioMed research international, 2018 - Wiley Online Library
Alpha‐ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical
role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the …

Antioxidant Effects of Different Extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus

RP Pereira, R Fachinetto, A de Souza Prestes… - Neurochemical …, 2009 - Springer
Considering the important role of oxidative stress in the pathogenesis of several
neurological diseases, and the growing evidence of the presence of compounds with …

Mutant p53-associated molecular mechanisms of ROS regulation in cancer cells

M Cordani, G Butera, R Pacchiana, F Masetto… - Biomolecules, 2020 - mdpi.com
The TP53 tumor suppressor gene is the most frequently altered gene in tumors and an
increasing number of studies highlight that mutant p53 proteins can acquire oncogenic …

New organochalcogen multitarget drug: Synthesis and antioxidant and antitumoral activities of chalcogenozidovudine derivatives

D de Souza, DOC Mariano, F Nedel… - Journal of medicinal …, 2015 - ACS Publications
In this article we present the synthesis, characterization, and in vitro biological and
biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of …

Diphenyl Diselenide Protects Against Mortality, Locomotor Deficits and Oxidative Stress in Drosophila melanogaster Model of Manganese-Induced Neurotoxicity

IA Adedara, AO Abolaji, JBT Rocha… - Neurochemical research, 2016 - Springer
Several experimental and epidemiological reports have associated manganese exposure
with induction of oxidative stress and locomotor dysfunctions. Diphenyl diselenide (DPDS) is …

Glutamate attenuates lipopolysaccharide-induced oxidative damage and mRNA expression changes of tight junction and defensin proteins, inflammatory and …

J Jiang, L Yin, JY Li, Q Li, D Shi, L Feng, Y Liu… - Fish & Shellfish …, 2017 - Elsevier
The present study explored the possible preventive effects of dietary glutamate (Glu) on LPS-
induced oxidative damage, mRNA expression changes of tight junction (TJ) and defensin …

Chemical composition, antioxidant and anticholinesterase activity of Melissa officinalis

RP Pereira, AA Boligon, AS Appel, R Fachinetto… - Industrial Crops and …, 2014 - Elsevier
Oxidative stress is associated with various diseases, in particular those related with the
central nervous system, such as Alzheimer's disease. Based on the various benefits of …

Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in …

AS de Freitas, VR Funck, M dos Santos Rotta… - Brain Research …, 2009 - Elsevier
Oxidative stress has been pointed out as an important molecular mechanism in
methylmercury (MeHg) intoxication. At low doses, diphenyl diselenide ((PhSe) 2), a …

Effect of reactive oxygen species overproduction on osteogenesis of porous titanium implant in the present of diabetes mellitus

YF Feng, L Wang, Y Zhang, X Li, ZS Ma, JW Zou, W Lei… - Biomaterials, 2013 - Elsevier
Clinical evidence indicates diabetes as a majorrisk factor for titaniumimplant treatment with
high failure rates and poor osteointegration, but the underlying mechanism involved remains …