Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans

V Fleischer, G Gonzalez-Escamilla… - Proceedings of the …, 2021 - National Acad Sciences
Neuroinflammation is a pathophysiological hallmark of multiple sclerosis and has a close
mechanistic link to neurodegeneration. Although this link is potentially targetable, robust …

A review on multiple sclerosis prognostic findings from imaging, inflammation, and mental health studies

J Brasanac, C Chien - Frontiers in Human Neuroscience, 2023 - frontiersin.org
Magnetic resonance imaging (MRI) of the brain is commonly used to detect where chronic
and active lesions are in multiple sclerosis (MS). MRI is also extensively used as a tool to …

Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy

S Klistorner, MH Barnett, J Parratt… - Annals of clinical …, 2022 - Wiley Online Library
Objectives Recent studies suggested that the expansion of long‐standing multiple sclerosis
(MS) lesions and an enlargement of choroid plexus may be linked to chronic inflammation …

Choroid plexus and perivascular space enlargement in neuropsychiatric systemic lupus erythematosus

M Gueye, P Preziosa, GA Ramirez, EP Bozzolo… - Molecular …, 2024 - nature.com
Choroid plexus (CP) enlargement is proposed as a marker of neuroinflammation in immune-
mediated conditions. CP involvement has also been hypothesized in the immunopathology …

Choroid plexus enlargement in paediatric multiple sclerosis: clinical relevance and effect of sex

M Margoni, M Gueye, A Meani, E Pagani… - Journal of Neurology …, 2023 - jnnp.bmj.com
Background Choroid plexus (CP) enlargement has been suggested as a reliable marker of
neuroinflammation in adult multiple sclerosis (MS). We investigated CP volume in patients …

Impairment of spinal CSF flow precedes immune cell infiltration in an active EAE model

L Xin, A Madarasz, DC Ivan, F Weber… - Journal of …, 2024 - Springer
Accumulation of immune cells and proteins in the subarachnoid space (SAS) is found during
multiple sclerosis and in the animal model experimental autoimmune encephalomyelitis …

Mechanisms of central brain atrophy in multiple sclerosis

S Klistorner, MH Barnett… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background: Change in ventricular volume has been suggested as surrogate measure of
central brain atrophy (CBA) applicable to the everyday management of multiple sclerosis …

Enlarged choroid plexus in multiple sclerosis is associated with increased lesion load and atrophy in white matter but not gray matter atrophy

T Akaishi, J Fujimori, I Nakashima - Multiple Sclerosis and Related …, 2024 - Elsevier
Background Enlargement of the choroid plexus (CP) is reported to associate with
inflammatory activity and contribute to brain atrophy in patients with multiple sclerosis …

Longitudinal evaluation of structural brain alterations in two established mouse models of Gulf War Illness

JM Carpenter, SN Hughes, NM Filipov - Frontiers in Neuroscience, 2024 - frontiersin.org
Gulf War Illness (GWI) affects nearly 30% of veterans from the 1990–1991 Gulf War (GW)
and is a multi-symptom illness with many neurological effects attributed to in-theater wartime …

Contribution of preclinical MRI to responsible animal research: living up to the 3R principle

L Wachsmuth, A Mensen, C Barca, M Wiart… - … Resonance Materials in …, 2021 - Springer
The contribution of preclinical MRI in advancing 3R efforts in the life sciences is undoubtedly
a hot area of discussion. For this reason, the 2nd ESMRMB preclinical MRI day “Frontiers in …