Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …

RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …

Biomolecular polyelectrolyte complexes can be formed between oppositely charged
intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly …

Werner syndrome (WS) is an accelerated ageing disorder with genomic instability caused by
WRN protein deficiency. Many features seen in WS can be explained by the diverse …

Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …

The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome
stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end …

This article reviews the currently used therapeutic strategies to target DNA replication stress
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …

DNA damage constantly threatens genome integrity, and DNA repair deficiency is
associated with increased cancer risk. An intuitive and widely accepted explanation for this …

Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in
diverse biological activities such as DNA replication, transcription, recombination and repair …

RECQL4 is a member of the evolutionarily conserved RecQ family of 3'to 5'DNA helicases.
RECQL4 is critical for maintaining genomic stability through its functions in DNA repair …