Osteosarcoma: molecular pathogenesis and iPSC modeling
Rare hereditary disorders provide unequivocal evidence of the importance of genes in
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …
human disease pathogenesis. Familial syndromes that predispose to osteosarcomagenesis …
[HTML][HTML] Human RecQ helicases in DNA double-strand break repair
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …
animals. These helicases play important roles in multiple cellular functions, including DNA …
[HTML][HTML] Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase
AC Papageorgiou, M Pospisilova, J Cibulka… - Nature …, 2023 - nature.com
Biomolecular polyelectrolyte complexes can be formed between oppositely charged
intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly …
intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly …
[HTML][HTML] WRN regulates pathway choice between classical and alternative non-homologous end joining
RA Shamanna, H Lu, JK De Freitas, J Tian… - Nature …, 2016 - nature.com
Werner syndrome (WS) is an accelerated ageing disorder with genomic instability caused by
WRN protein deficiency. Many features seen in WS can be explained by the diverse …
WRN protein deficiency. Many features seen in WS can be explained by the diverse …
[HTML][HTML] Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …
to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome …
[HTML][HTML] RECQL4 promotes DNA end resection in repair of DNA double-strand breaks
The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome
stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end …
stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end …
[HTML][HTML] Therapeutic targeting of DNA replication stress in cancer
L Gu, RJ Hickey, LH Malkas - Genes, 2023 - mdpi.com
This article reviews the currently used therapeutic strategies to target DNA replication stress
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …
[HTML][HTML] Human variation in DNA repair, immune function, and cancer risk
A Cheong, ZD Nagel - Frontiers in immunology, 2022 - frontiersin.org
DNA damage constantly threatens genome integrity, and DNA repair deficiency is
associated with increased cancer risk. An intuitive and widely accepted explanation for this …
associated with increased cancer risk. An intuitive and widely accepted explanation for this …
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells
D Mo, Y Zhao, AS Balajee - Cancer letters, 2018 - Elsevier
Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in
diverse biological activities such as DNA replication, transcription, recombination and repair …
diverse biological activities such as DNA replication, transcription, recombination and repair …
[HTML][HTML] Role and regulation of the RECQL4 family during genomic integrity maintenance
TT Luong, KA Bernstein - Genes, 2021 - mdpi.com
RECQL4 is a member of the evolutionarily conserved RecQ family of 3'to 5'DNA helicases.
RECQL4 is critical for maintaining genomic stability through its functions in DNA repair …
RECQL4 is critical for maintaining genomic stability through its functions in DNA repair …