Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …

Tumors of the colorectum are amongst the most comof the new discoveries that are relevant
to colorectal mon human neoplasms. Approximately 5% of the Westcancer in humans have …

The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces
such as fibrotic stiffness or mechanical pressure caused by the expansion of hyper …

Overexpression of cell surface glycoproteins of the CD44 family is an early event in the
colorectal adenoma-carcinoma sequence. This suggests a link with disruption of APC tumor …

Abstract The DPC4 (SMAD4) gene plays a key role in the TGFβ signaling pathway. We
inactivated its mouse homolog Dpc4 (Smad4). The homozygous mutants were embryonic …

The marked diversity in the phenotype of intestinal neoplasia in murine models offers
opportunities to model many characteristics of human CRC, including tumor progression …

The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an
inherited syndrome of colon cancer predisposition known as familial adenomatous …

According to the classical interpretation of Knudson's 'two-hit'hypothesis for tumorigenesis,
the two 'hits' are independent mutation events, the end result of which is loss of a tumor …

Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal
tumorigenesis. Existing mouse intestinal tumor models display mainly small intestinal …

Background & Aims: Synchronous activation of the Wnt signaling pathway, mostly because
of loss of function of the APC tumor suppressor, and of the oncogenic KRAS-signaling …