Because each nonlinear optical (NLO) imaging modality is sensitive to specific molecules or
structures, multimodal NLO imaging capitalizes the potential of NLO microscopy for studies …

Despite the ubiquitous roles of lipids in biology, the detection of lipids has relied on invasive
techniques, population measurements, or nonspecific labeling. Such difficulties can be …

Purpose.: Photochemical cross-linking of corneal collagen is an evolving treatment for
keratoconus and other ectatic disorders. We evaluated collagen cross-linking by rose …

Conventional histopathology with hematoxylin & eosin (H&E) has been the gold standard for
histopathological diagnosis of a wide range of diseases. However, it is not performed in vivo …

The study of amyotrophic lateral sclerosis (ALS) and potential interventions would be
facilitated if motor axon degeneration could be more readily visualized. Here we …

Characterizing precisely the microstructure of axons, their density, size and myelination is of
interest for the neuroscientific community, for example to help maximize the outcome of …

Optical imaging with spectroscopic vibrational contrast is a label-free solution for visualizing,
identifying, and quantifying a wide range of biomolecular compounds in biological materials …

We demonstrate a fiber-based probe for maximum collection of the coherent anti-Stokes
Raman scattering (CARS) signal in biological tissues. We discuss the design challenges …

Modern optical microscopy has granted biomedical scientists unprecedented access to the
inner workings of a cell, and revolutionized our understanding of the molecular mechanisms …

High-frequency electrical stimulation is becoming a promising therapy for neurological
disorders, however the response of the central nervous system to stimulation remains poorly …