Telomerase regulation: a role for epigenetics
F Dogan, NR Forsyth - Cancers, 2021 - mdpi.com
Simple Summary Maintenance of telomeres is a fundamental step in human carcinogenesis
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …
and is primarily regulated by telomerase and the human telomerase reverse transcriptase …
ALT: A multi-faceted phenomenon
A Sommer, NJ Royle - Genes, 2020 - mdpi.com
One of the hallmarks of cancer cells is their indefinite replicative potential, made possible by
the activation of a telomere maintenance mechanism (TMM). The majority of cancers …
the activation of a telomere maintenance mechanism (TMM). The majority of cancers …
Epigenetic regulation of telomere maintenance for therapeutic interventions in gliomas
E Naderlinger, K Holzmann - Genes, 2017 - mdpi.com
High-grade astrocytoma of WHO grade 4 termed glioblastoma multiforme (GBM) is a
common human brain tumor with poor patient outcome. Astrocytoma demonstrates two …
common human brain tumor with poor patient outcome. Astrocytoma demonstrates two …
Promoter conservation in HDACs points to functional implications
Abstract Background Histone deacetylases (HDACs) are the proteins responsible for
removing the acetyl group from lysine residues of core histones in chromosomes, a crucial …
removing the acetyl group from lysine residues of core histones in chromosomes, a crucial …
Clinical significance of HDAC9 in hepatocellular carcinoma
Y Hu, L Sun, S Tao, M Dai, Y Wang… - Cellular and Molecular …, 2019 - mail.cellmolbiol.org
In recent years, most related studies have found that chronic hepatitis B virus infection is the
main cause of hepatocellular carcinoma (HCC), but the specific pathogenesis is still unclear …
main cause of hepatocellular carcinoma (HCC), but the specific pathogenesis is still unclear …
Identification of key proteins from the alternative lengthening of telomeres-associated promyelocytic leukemia nuclear bodies pathway
I Armendáriz-Castillo, K Hidalgo-Fernández… - Biology, 2022 - mdpi.com
Simple Summary The alternative lengthening of telomeres is a telomere maintenance
mechanism used by some cancer types to elongate their telomeres without the aid of …
mechanism used by some cancer types to elongate their telomeres without the aid of …
组蛋白去乙酰化酶9 在肿瘤中的作用
付洋, 孔垂泽 - 中国肿瘤临床, 2018 - cjco.cn
组蛋白去乙酰化酶9 (histone deacetylase 9, HDAC9) 属于组蛋白去乙酰化酶(histone
deacetylases, HDACs) Ⅱa 亚型, 在体内通过催化组蛋白3 (H3), 组蛋白4 (H4) …
deacetylases, HDACs) Ⅱa 亚型, 在体内通过催化组蛋白3 (H3), 组蛋白4 (H4) …
组蛋白去乙酰化酶9 在骨髓间充质干细胞衰老过程中的表达
詹渊博, 刘昕朋, 许文霞, 苗楠, 穆森, 张瑞敏, 李莹 - 中国组织工程研究, 2022 - cjter.com
组蛋白去乙酰化酶9 在骨髓间充质干细胞衰老过程中的表达 Page 1 4762|中国组织工程研究|第
26卷|第30期|2022年10月 中国组织工程研究 Chinese Journal of Tissue Engineering Research …
26卷|第30期|2022年10月 中国组织工程研究 Chinese Journal of Tissue Engineering Research …
The Genetic Basis of Neuroendocrine Neoplasms
AR Wasylishen, CM Gay, DM Halperin - Neuroendocrine Neoplasia, 2024 - Springer
Neuroendocrine neoplasms (NENs) represent a diverse collection of malignancies with
heterogenous cell and tissue of origin, clinical behavior, and genetic underpinnings. This …
heterogenous cell and tissue of origin, clinical behavior, and genetic underpinnings. This …
Hot spot TERT promoter mutations are rare in sporadic pancreatic neuroendocrine neoplasms and associated with telomere length and epigenetic expression …
A Posch, S Hofer-Zeni, E Klieser, F Primavesi… - Cancers, 2020 - mdpi.com
Cancer cells activate a telomere maintenance mechanism like telomerase in order to
proliferate indefinitely. Telomerase can be reactivated by gain-of-function Telomerase …
proliferate indefinitely. Telomerase can be reactivated by gain-of-function Telomerase …