RNA-binding proteins in cancer: old players and new actors
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …
combination of versatility of their RNA-binding domains with structural flexibility enables …
The LIN28/let-7 pathway in cancer
Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …
[HTML][HTML] Stability of the hybrid epithelial/mesenchymal phenotype
Abstract Epithelial-to-Mesenchymal Transition (EMT) and its reverse–Mesenchymal to
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer
X Huang, H Zhang, X Guo, Z Zhu, H Cai… - Journal of hematology & …, 2018 - Springer
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in
embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner …
embryogenesis and carcinogenesis. IGF2BP1 serves as a post-transcriptional fine-tuner …
Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
E Chirshev, KC Oberg, YJ Ioffe… - Clinical and translational …, 2019 - Springer
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
[HTML][HTML] Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms
E Piskounova, C Polytarchou, JE Thornton… - Cell, 2011 - cell.com
Summary Lin28A and Lin28B selectively block the expression of let-7 microRNAs and
function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase …
function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase …
Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
including splicing, cleavage and polyadenylation, transport, translation and degradation of …
Ovarian cancers: genetic abnormalities, tumor heterogeneity and progression, clonal evolution and cancer stem cells
Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …
A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer
J Verstappe, G Berx - Seminars in Cancer Biology, 2023 - Elsevier
Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …