Assessment of Inner Blood–Retinal Barrier: Animal Models and Methods
Proper functioning of the neural retina relies on the unique retinal environment regulated by
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …
Selective activation of the Wnt-signaling pathway as a novel therapy for the treatment of diabetic retinopathy and other retinal vascular diseases
Retinal ischemia, often associated with various disorders such as diabetic retinopathy (DR),
retinal vein occlusion, glaucoma, optic neuropathies, stroke, and other retinopathies, is a …
retinal vein occlusion, glaucoma, optic neuropathies, stroke, and other retinopathies, is a …
[HTML][HTML] Defective EMC1 drives abnormal retinal angiogenesis via Wnt/β-catenin signaling and may be associated with the pathogenesis of familial exudative …
S Li, M Yang, R Zhao, L Peng, W Liu, X Jiang, Y He… - Genes & …, 2023 - Elsevier
Endoplasmic reticulum (ER) membrane protein complex (EMC) is required for the co-
translational insertion of newly synthesized multi-transmembrane proteins. Compromised …
translational insertion of newly synthesized multi-transmembrane proteins. Compromised …
Frameshift variants in the C-terminal of CTNNB1 cause familial exudative vitreoretinopathy by AXIN1-mediated ubiquitin-proteasome degradation condensation
The β-catenin has two intrinsically disordered regions in both C-and N-terminal domains that
trigger the formation of phase-separated condensates. Variants in its C-terminus are …
trigger the formation of phase-separated condensates. Variants in its C-terminus are …
Clinical characteristics and mutation spectrum in 33 Chinese families with familial exudative vitreoretinopathy
J Mao, Y Chen, Y Fang, Y Shao, Z Xiang, H Li… - Annals of …, 2022 - Taylor & Francis
Objective To explore the clinical manifestations and search for the variants of six related
genes (LRP5, FZD4, TSPAN12, NDP, KIF11 and ZNF408) in Chinese patients with familial …
genes (LRP5, FZD4, TSPAN12, NDP, KIF11 and ZNF408) in Chinese patients with familial …
A comprehensive functional analysis on the pathogenesis of novel TSPAN12 and NDP variants in familial exudative vitreoretinopathy
R Zhao, E Dai, S Wang, X Zhang, Y He… - Clinical …, 2023 - Wiley Online Library
Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder; however, the
known FEVR‐associated variants account for approximately only 50% cases. Currently, the …
known FEVR‐associated variants account for approximately only 50% cases. Currently, the …
Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy
W Liu, S Li, M Yang, J Ma, L Liu, P Fei, Q Xiang… - Elife, 2024 - elifesciences.org
Familial exudative vitreoretinopathy (FEVR) is a severe genetic disorder characterized by
incomplete vascularization of the peripheral retina and associated symptoms that can lead …
incomplete vascularization of the peripheral retina and associated symptoms that can lead …
[HTML][HTML] Familial Exudative Vitreoretinopathy With and Without Pathogenic Variants of Norrin/β-Catenin Signaling Genes
H Kondo, T Tsukahara-Kawamura, I Matsushita… - Ophthalmology …, 2024 - Elsevier
Purpose To determine the clinical characteristics of familial exudative vitreoretinopathy
(FEVR) associated with or without pathogenic variants of the Norrin/β-catenin genes. Design …
(FEVR) associated with or without pathogenic variants of the Norrin/β-catenin genes. Design …
[HTML][HTML] Progress in the development of Modulators targeting Frizzleds
J Chuan, W Li, S Pan, Z Jiang, J Shi, Z Yang - Pharmacological Research, 2024 - Elsevier
Abstract The Frizzleds (FZDs) receptors on the cell surface belong to the class F of G protein-
coupled receptors (GPCRs) which are the major receptors of WNT protein that mediates the …
coupled receptors (GPCRs) which are the major receptors of WNT protein that mediates the …
Deciphering a crucial dimeric interface governing Norrin dimerization and the pathogenesis of familial exudative vitreoretinopathy
R Zhao, M Liu, E Dai, C Chen, L Lv, L Peng… - The FASEB …, 2024 - Wiley Online Library
Familial exudative vitreoretinopathy (FEVR) is a hereditary eye disease that could cause
blindness. It has been established that Norrin forms dimers to activate β‐catenin signaling …
blindness. It has been established that Norrin forms dimers to activate β‐catenin signaling …