Large scale brain models of epilepsy: dynamics meets connectomics
MP Richardson - Journal of Neurology, Neurosurgery & Psychiatry, 2012 - jnnp.bmj.com
The brain is in a constant state of dynamic change, for example switching between cognitive
and behavioural tasks, and between wakefulness and sleep. The brains of people with …
and behavioural tasks, and between wakefulness and sleep. The brains of people with …
Juvenile myoclonic epilepsy: a system disorder of the brain
P Wolf, EMT Yacubian, G Avanzini, T Sander… - Epilepsy research, 2015 - Elsevier
The prevailing understanding of generalized epilepsy is shaped by the traditional definition
that “the responsible neuronal discharge takes place, if not throughout the entire grey matter …
that “the responsible neuronal discharge takes place, if not throughout the entire grey matter …
Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy
Juvenile myoclonic epilepsy is the most common idiopathic generalized epilepsy,
characterized by frequent myoclonic jerks, generalized tonic-clonic seizures and, less …
characterized by frequent myoclonic jerks, generalized tonic-clonic seizures and, less …
Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy
Objective: The aim of this study was to determine if there were focal cortical abnormalities in
juvenile myoclonic epilepsy (JME) using neuropsychological investigations and MRI …
juvenile myoclonic epilepsy (JME) using neuropsychological investigations and MRI …
Thalamo–cortical network pathology in idiopathic generalized epilepsy: insights from MRI-based morphometric correlation analysis
BC Bernhardt, DA Rozen, KJ Worsley, AC Evans… - Neuroimage, 2009 - Elsevier
Epileptic activity underlying idiopathic generalized epilepsy (IGE) is related to abnormal
thalamo–cortical interactions. Our purpose was to map in vivo the organization of the …
thalamo–cortical interactions. Our purpose was to map in vivo the organization of the …
Thalamofrontal circuitry and executive dysfunction in recent‐onset juvenile myoclonic epilepsy
DT Pulsipher, M Seidenberg, L Guidotti… - …, 2009 - Wiley Online Library
Purpose: Thalamofrontal abnormalities have been identified in chronic primary generalized
epilepsy, specifically in juvenile myoclonic epilepsy (JME). These regions also underlie …
epilepsy, specifically in juvenile myoclonic epilepsy (JME). These regions also underlie …
Altered thalamocortical functional connectivity in idiopathic generalized epilepsy
Objective Aberrant thalamocortical network has been hypothesized to play a crucial role in
the fundamental pathogenesis underlying idiopathic generalized epilepsy (IGE). We aimed …
the fundamental pathogenesis underlying idiopathic generalized epilepsy (IGE). We aimed …
Focal abnormalities in idiopathic generalized epilepsy: a critical review of the literature
Conventionally, epilepsy is dichotomized into distinct “focal” and “generalized” categories.
However, many studies have reported so‐called focal features among patients with …
However, many studies have reported so‐called focal features among patients with …
Cortical and subcortical contributions to absence seizure onset examined with EEG/fMRI
In patients with idiopathic generalized epilepsies (IGEs), bursts of generalized spike and
wave discharges (GSWDs) lasting≥ 2seconds are considered absence seizures. The …
wave discharges (GSWDs) lasting≥ 2seconds are considered absence seizures. The …
Connectivity of the supplementary motor area in juvenile myoclonic epilepsy and frontal lobe epilepsy
Purpose: Subtle structural abnormalities of frontal lobe gray and white matter have been
described in cryptogenic frontal lobe and idiopathic generalized epilepsies. The …
described in cryptogenic frontal lobe and idiopathic generalized epilepsies. The …