A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists
W Liu, X Jiang, Y Zu, Y Yang, Y Liu, X Sun, Z Xu… - European journal of …, 2020 - Elsevier
Abstract l-glutamate is an excitatory neurotransmitter in the central nervous system (CNS),
which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N …
which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N …
GluN2B subunit selective N-methyl-D-aspartate receptor ligands: Democratizing recent progress to assist the development of novel neurotherapeutics
V Ugale, R Deshmukh, D Lokwani… - Molecular Diversity, 2024 - Springer
N-methyl-D-aspartate receptors (NMDARs) play essential roles in vital aspects of brain
functions. NMDARs mediate clinical features of neurological diseases and thus, represent a …
functions. NMDARs mediate clinical features of neurological diseases and thus, represent a …
Design, synthesis and evaluation of novel 1-phenyl-pyrrolo [1, 2-b] isoquinolin-3-one derivatives as antagonists for the glycine binding site of the NMDA receptor
L Yang, H Liu, E Wang, H Liu, H Liu, L Zhou… - European Journal of …, 2023 - Elsevier
A new series of 1-phenyl-pyrrolo [1, 2-b] isoquinolin-3-one derivatives were designed,
synthesized and demonstrated to act as antagonists for the glycine binding site of the NMDA …
synthesized and demonstrated to act as antagonists for the glycine binding site of the NMDA …
Discovery of novel tryptamine derivatives as GluN2B subunit-containing NMDA receptor antagonists via pharmacophore-merging strategy with orally available …
J Quan, H Yang, F Qin, Y He, J Liu, Y Zhao… - European Journal of …, 2023 - Elsevier
A series of tryptamine derivatives has been designed and synthesized as novel GluN2B
subunit-containing NMDA receptor (GluN2B-NMDAR) antagonists, which could …
subunit-containing NMDA receptor (GluN2B-NMDAR) antagonists, which could …
Pd (II)-catalyzed [5+ 2] rollover annulation and lactonization of 1-benzylpyrazoles with 4-hydroxy-2-alkynoates
SR Kancharla, R Bantu, B Sridhar, AV Narsaiah… - Tetrahedron, 2024 - Elsevier
Abstract The first Pd-catalyzed [5+ 2] rollover annulation of 1-benzylpyrazoles has been
developed to afford a novel class of 1H-benzo [e] furo [3, 4-c] pyrazolo [1, 5-a] azepin-3 (8H) …
developed to afford a novel class of 1H-benzo [e] furo [3, 4-c] pyrazolo [1, 5-a] azepin-3 (8H) …
Synthesis of novel 1-phenyl-benzopyrrolizidin-3-one derivatives and evaluation of their cytoneuroprotective effects against NMDA-induced injury in PC12 cells
L Yang, Q Yang, E Wang, J Yang, Q Li, J Cao… - Bioorganic & Medicinal …, 2022 - Elsevier
A range of novel 1-phenyl-benzopyrrolizidin-3-one derivatives were synthesized and
evaluated for neuroprotective effects against N-methyl-ᴅ-aspartate (NMDA)-induced injury …
evaluated for neuroprotective effects against N-methyl-ᴅ-aspartate (NMDA)-induced injury …
A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors
JA Schreiber, D Schepmann, B Frehland… - Communications …, 2019 - nature.com
N-methyl-d-aspartate receptors (NMDARs), especially GluN2B-containing NMDARs, are
associated with neurodegenerative diseases like Parkinson, Alzheimer and Huntington …
associated with neurodegenerative diseases like Parkinson, Alzheimer and Huntington …
Cadmium Sulfide Quantum‐Dot‐Photocatalyzed Cascade Cyclization of Functionalized Difluoromethyl Chlorides with Unactivated Olefins
J Hu, TJ Pu, ZW Xu, WY Xu… - Advanced Synthesis & …, 2019 - Wiley Online Library
A cadmium sulfide quantum‐dot‐photocatalyzed C (sp3)− Cl bond cleavage of ethyl
chlorodifluoroacetate and cascade cyclization with unactivated olefins is described herein …
chlorodifluoroacetate and cascade cyclization with unactivated olefins is described herein …
Asymmetric Synthesis of 1-Benzazepine Derivatives via Copper-Catalyzed Intramolecular Reductive Cyclization
An asymmetric construction of enantioenriched 2, 3-substituted-1-benzazepine derivatives
containing a cyclic tertiary amine moiety was developed by copper-catalyzed reductive …
containing a cyclic tertiary amine moiety was developed by copper-catalyzed reductive …
Design, synthesis, pharmacological evaluation and docking studies of GluN2B‐selective NMDA receptor antagonists with a benzo [7] annulen‐7‐amine scaffold
S Gawaskar, L Temme, JA Schreiber… - …, 2017 - Wiley Online Library
Antagonists that selectively target GluN2B‐subunit‐containing N‐methyl‐d‐aspartate
(NMDA) receptors are of major interest for the treatment of various neurological disorders. In …
(NMDA) receptors are of major interest for the treatment of various neurological disorders. In …